node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C19orf40 | PNMA2 | ENSP00000466121 | ENSP00000429344 | chromosome 19 open reading frame 40; Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA | paraneoplastic Ma antigen 2 | 0.664 |
C19orf40 | RMI1 | ENSP00000466121 | ENSP00000317039 | chromosome 19 open reading frame 40; Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae); Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability | 0.961 |
C19orf40 | TELO2 | ENSP00000466121 | ENSP00000262319 | chromosome 19 open reading frame 40; Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA | TEL2, telomere maintenance 2, homolog (S. cerevisiae); Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complex [...] | 0.962 |
DPYSL5 | PNMA2 | ENSP00000288699 | ENSP00000429344 | dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth | paraneoplastic Ma antigen 2 | 0.636 |
PARD6G | PNMA2 | ENSP00000343144 | ENSP00000429344 | par-6 partitioning defective 6 homolog gamma (C. elegans); Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP- bound Rho small GTPases to atypical protein kinase C proteins (By similarity) | paraneoplastic Ma antigen 2 | 0.667 |
PARD6G | YWHAZ | ENSP00000343144 | ENSP00000309503 | par-6 partitioning defective 6 homolog gamma (C. elegans); Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP- bound Rho small GTPases to atypical protein kinase C proteins (By similarity) | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.461 |
PNMA1 | PNMA2 | ENSP00000318914 | ENSP00000429344 | paraneoplastic Ma antigen 1 | paraneoplastic Ma antigen 2 | 0.729 |
PNMA1 | PRDM10 | ENSP00000318914 | ENSP00000351686 | paraneoplastic Ma antigen 1 | PR domain containing 10 | 0.480 |
PNMA1 | YWHAZ | ENSP00000318914 | ENSP00000309503 | paraneoplastic Ma antigen 1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.489 |
PNMA2 | C19orf40 | ENSP00000429344 | ENSP00000466121 | paraneoplastic Ma antigen 2 | chromosome 19 open reading frame 40; Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA | 0.664 |
PNMA2 | DPYSL5 | ENSP00000429344 | ENSP00000288699 | paraneoplastic Ma antigen 2 | dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth | 0.636 |
PNMA2 | PARD6G | ENSP00000429344 | ENSP00000343144 | paraneoplastic Ma antigen 2 | par-6 partitioning defective 6 homolog gamma (C. elegans); Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP- bound Rho small GTPases to atypical protein kinase C proteins (By similarity) | 0.667 |
PNMA2 | PNMA1 | ENSP00000429344 | ENSP00000318914 | paraneoplastic Ma antigen 2 | paraneoplastic Ma antigen 1 | 0.729 |
PNMA2 | PRDM10 | ENSP00000429344 | ENSP00000351686 | paraneoplastic Ma antigen 2 | PR domain containing 10 | 0.586 |
PNMA2 | RMI1 | ENSP00000429344 | ENSP00000317039 | paraneoplastic Ma antigen 2 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae); Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability | 0.663 |
PNMA2 | RNF8 | ENSP00000429344 | ENSP00000362578 | paraneoplastic Ma antigen 2 | ring finger protein 8, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles- by mediating the ’Lys-63’- linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing ’Lys-48’-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the ’Lys-63’-linked ubiquitination of histones H2A and H2AX, thereby promoting th [...] | 0.669 |
PNMA2 | TELO2 | ENSP00000429344 | ENSP00000262319 | paraneoplastic Ma antigen 2 | TEL2, telomere maintenance 2, homolog (S. cerevisiae); Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complex [...] | 0.660 |
PNMA2 | TIPARP | ENSP00000429344 | ENSP00000295924 | paraneoplastic Ma antigen 2 | TCDD-inducible poly(ADP-ribose) polymerase; Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity) | 0.812 |
PNMA2 | YWHAZ | ENSP00000429344 | ENSP00000309503 | paraneoplastic Ma antigen 2 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.624 |
PRDM10 | PNMA1 | ENSP00000351686 | ENSP00000318914 | PR domain containing 10 | paraneoplastic Ma antigen 1 | 0.480 |