node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP5D | FAM92A1 | ENSP00000215375 | ENSP00000429367 | ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled vi [...] | family with sequence similarity 92, member A1 | 0.544 |
CBY1 | FAM92A1 | ENSP00000216029 | ENSP00000429367 | chibby homolog 1 (Drosophila); Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation | family with sequence similarity 92, member A1 | 0.613 |
DIS3L | FAM92A1 | ENSP00000321711 | ENSP00000429367 | DIS3 mitotic control homolog (S. cerevisiae)-like; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA | family with sequence similarity 92, member A1 | 0.485 |
FAM92A1 | ATP5D | ENSP00000429367 | ENSP00000215375 | family with sequence similarity 92, member A1 | ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled vi [...] | 0.544 |
FAM92A1 | CBY1 | ENSP00000429367 | ENSP00000216029 | family with sequence similarity 92, member A1 | chibby homolog 1 (Drosophila); Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation | 0.613 |
FAM92A1 | DIS3L | ENSP00000429367 | ENSP00000321711 | family with sequence similarity 92, member A1 | DIS3 mitotic control homolog (S. cerevisiae)-like; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA | 0.485 |
FAM92A1 | FLAD1 | ENSP00000429367 | ENSP00000292180 | family with sequence similarity 92, member A1 | FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae); Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme | 0.485 |
FAM92A1 | RPAP2 | ENSP00000429367 | ENSP00000359368 | family with sequence similarity 92, member A1 | RNA polymerase II associated protein 2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated ’Ser-7’ of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of ’Ser-5’ of the CTD, thereby promoting transcription of snRNA genes | 0.418 |
FAM92A1 | SMEK1 | ENSP00000429367 | ENSP00000337125 | family with sequence similarity 92, member A1 | SMEK homolog 1, suppressor of mek1 (Dictyostelium) | 0.414 |
FAM92A1 | UROC1 | ENSP00000429367 | ENSP00000373073 | family with sequence similarity 92, member A1 | urocanate hydratase 1 | 0.471 |
FLAD1 | FAM92A1 | ENSP00000292180 | ENSP00000429367 | FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae); Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme | family with sequence similarity 92, member A1 | 0.485 |
RPAP2 | FAM92A1 | ENSP00000359368 | ENSP00000429367 | RNA polymerase II associated protein 2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated ’Ser-7’ of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of ’Ser-5’ of the CTD, thereby promoting transcription of snRNA genes | family with sequence similarity 92, member A1 | 0.418 |
SMEK1 | FAM92A1 | ENSP00000337125 | ENSP00000429367 | SMEK homolog 1, suppressor of mek1 (Dictyostelium) | family with sequence similarity 92, member A1 | 0.414 |
UROC1 | FAM92A1 | ENSP00000373073 | ENSP00000429367 | urocanate hydratase 1 | family with sequence similarity 92, member A1 | 0.471 |