Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | ETV3L | ets variant 3-like; Transcriptional regulator (By similarity) (361 aa) | ||||||||||||
Predicted Functional Partners:
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 | LYRM2 | LYR motif containing 2 (88 aa) |
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0.566 | ||||||||||
 | C20orf26 | chromosome 20 open reading frame 26 (1237 aa) |
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0.565 | ||||||||||
 | ZNF283 | zinc finger protein 283; May be involved in transcriptional regulation (679 aa) |
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0.514 | ||||||||||
 | SIRPB2 | signal-regulatory protein beta 2 (342 aa) |
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0.510 | ||||||||||
 | MAATS1 | MYCBP/AMY-1-associated, testis expressed 1 (767 aa) |
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0.510 | ||||||||||
 | JUN | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (331 aa) |
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0.508 | |||||||||
 | JUNB | jun B proto-oncogene; Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5’-TGA[CG]TCA-3’ (347 aa) |
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0.508 | |||||||||
 | JUND | jun D proto-oncogene; Transcription factor binding AP-1 sites (347 aa) |
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0.508 | |||||||||
 | TMEM214 | transmembrane protein 214 (689 aa) |
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0.501 | ||||||||||
 | TBC1D8B | TBC1 domain family, member 8B (with GRAM domain); May act as a GTPase-activating protein for Rab family protein(s) (1120 aa) |
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0.499 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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