node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GUCY1A2 | GUCY1B3 | ENSP00000431245 | ENSP00000264424 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | guanylate cyclase 1, soluble, beta 3 | 0.960 |
GUCY1A2 | NOS3 | ENSP00000431245 | ENSP00000297494 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | 0.935 |
GUCY1A2 | PDE10A | ENSP00000431245 | ENSP00000438284 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate | 0.940 |
GUCY1A2 | PDE11A | ENSP00000431245 | ENSP00000286063 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | phosphodiesterase 11A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5’-AMP and 5’- GMP, respectively | 0.940 |
GUCY1A2 | PDE2A | ENSP00000431245 | ENSP00000334910 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | phosphodiesterase 2A, cGMP-stimulated; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes | 0.940 |
GUCY1A2 | PDE5A | ENSP00000431245 | ENSP00000347046 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | phosphodiesterase 5A, cGMP-specific; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5’- GMP | 0.941 |
GUCY1A2 | PDE6A | ENSP00000431245 | ENSP00000255266 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | phosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal | 0.940 |
GUCY1A2 | PDE6B | ENSP00000431245 | ENSP00000420295 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | 0.940 |
GUCY1A2 | PDE6C | ENSP00000431245 | ENSP00000360502 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | phosphodiesterase 6C, cGMP-specific, cone, alpha prime | 0.940 |
GUCY1A2 | PDE9A | ENSP00000431245 | ENSP00000291539 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | phosphodiesterase 9A | 0.940 |
GUCY1B3 | GUCY1A2 | ENSP00000264424 | ENSP00000431245 | guanylate cyclase 1, soluble, beta 3 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | 0.960 |
GUCY1B3 | NOS3 | ENSP00000264424 | ENSP00000297494 | guanylate cyclase 1, soluble, beta 3 | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | 0.977 |
GUCY1B3 | PDE10A | ENSP00000264424 | ENSP00000438284 | guanylate cyclase 1, soluble, beta 3 | phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate | 0.941 |
GUCY1B3 | PDE11A | ENSP00000264424 | ENSP00000286063 | guanylate cyclase 1, soluble, beta 3 | phosphodiesterase 11A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5’-AMP and 5’- GMP, respectively | 0.940 |
GUCY1B3 | PDE2A | ENSP00000264424 | ENSP00000334910 | guanylate cyclase 1, soluble, beta 3 | phosphodiesterase 2A, cGMP-stimulated; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes | 0.946 |
GUCY1B3 | PDE5A | ENSP00000264424 | ENSP00000347046 | guanylate cyclase 1, soluble, beta 3 | phosphodiesterase 5A, cGMP-specific; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5’- GMP | 0.947 |
GUCY1B3 | PDE6A | ENSP00000264424 | ENSP00000255266 | guanylate cyclase 1, soluble, beta 3 | phosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal | 0.940 |
GUCY1B3 | PDE6B | ENSP00000264424 | ENSP00000420295 | guanylate cyclase 1, soluble, beta 3 | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | 0.940 |
GUCY1B3 | PDE6C | ENSP00000264424 | ENSP00000360502 | guanylate cyclase 1, soluble, beta 3 | phosphodiesterase 6C, cGMP-specific, cone, alpha prime | 0.945 |
GUCY1B3 | PDE9A | ENSP00000264424 | ENSP00000291539 | guanylate cyclase 1, soluble, beta 3 | phosphodiesterase 9A | 0.940 |