Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | C12orf55 | chromosome 12 open reading frame 55 (3096 aa) | ||||||||||||
Predicted Functional Partners:
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 | TMEM156 | transmembrane protein 156 (296 aa) |
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0.658 | ||||||||||
 | METTL25 | methyltransferase like 25; Putative methyltransferase (By similarity) (603 aa) |
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0.583 | ||||||||||
 | FAM92B | family with sequence similarity 92, member B (304 aa) |
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0.582 | ||||||||||
 | NUGGC | nuclear GTPase, germinal center associated; Plays a role as replication-related GTPase protein in germinal center B-cell (796 aa) |
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0.566 | ||||||||||
 | CEACAM21 | carcinoembryonic antigen-related cell adhesion molecule 21 (293 aa) |
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0.508 | ||||||||||
 | BARHL1 | BarH-like homeobox 1 (327 aa) |
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0.483 | ||||||||||
 | FCRL1 | Fc receptor-like 1; May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation (429 aa) |
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0.472 | ||||||||||
 | CPNE5 | copine V; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) (593 aa) |
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0.472 | ||||||||||
 | MEI1 | meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity) (1274 aa) |
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0.471 | ||||||||||
 | FGD6 | FYVE, RhoGEF and PH domain containing 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity) (1430 aa) |
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0.421 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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