| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASIP | MC1R | ENSP00000364092 | ENSP00000451605 | agouti signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | 0.982 |
| ASIP | OCA2 | ENSP00000364092 | ENSP00000346659 | agouti signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | 0.608 |
| ASIP | SLC24A4 | ENSP00000364092 | ENSP00000431840 | agouti signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.609 |
| ASIP | SLC45A2 | ENSP00000364092 | ENSP00000296589 | agouti signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes | solute carrier family 45, member 2; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity) | 0.472 |
| ASIP | TPCN2 | ENSP00000364092 | ENSP00000294309 | agouti signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes | two pore segment channel 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction | 0.608 |
| ASIP | TYRP1 | ENSP00000364092 | ENSP00000373570 | agouti signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes | tyrosinase-related protein 1; Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized | 0.545 |
| BPTF | SLC24A4 | ENSP00000307208 | ENSP00000431840 | bromodomain PHD finger transcription factor; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.503 |
| HERC2 | MC1R | ENSP00000261609 | ENSP00000451605 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | 0.567 |
| HERC2 | OCA2 | ENSP00000261609 | ENSP00000346659 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | 0.760 |
| HERC2 | SLC24A4 | ENSP00000261609 | ENSP00000431840 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.609 |
| HERC2 | SLC45A2 | ENSP00000261609 | ENSP00000296589 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | solute carrier family 45, member 2; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity) | 0.563 |
| HERC2 | TPCN2 | ENSP00000261609 | ENSP00000294309 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | two pore segment channel 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction | 0.517 |
| ITPK1 | SLC24A4 | ENSP00000267615 | ENSP00000431840 | inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate I [...] | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.488 |
| MC1R | ASIP | ENSP00000451605 | ENSP00000364092 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | agouti signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes | 0.982 |
| MC1R | HERC2 | ENSP00000451605 | ENSP00000261609 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | 0.567 |
| MC1R | OCA2 | ENSP00000451605 | ENSP00000346659 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | 0.823 |
| MC1R | SLC24A4 | ENSP00000451605 | ENSP00000431840 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.561 |
| MC1R | SLC45A2 | ENSP00000451605 | ENSP00000296589 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | solute carrier family 45, member 2; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity) | 0.658 |
| MC1R | TPCN2 | ENSP00000451605 | ENSP00000294309 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | two pore segment channel 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction | 0.457 |
| MC1R | TYRP1 | ENSP00000451605 | ENSP00000373570 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | tyrosinase-related protein 1; Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized | 0.771 |
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