node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEF1D | RPL27A | ENSP00000391944 | ENSP00000346015 | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein); Isoform 1- EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome | ribosomal protein L27a | 0.745 |
EEF1D | RPL5 | ENSP00000391944 | ENSP00000359345 | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein); Isoform 1- EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome | ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA | 0.780 |
EEF1D | RPS15 | ENSP00000391944 | ENSP00000467676 | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein); Isoform 1- EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome | ribosomal protein S15 | 0.766 |
EEF1D | RPS2 | ENSP00000391944 | ENSP00000341885 | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein); Isoform 1- EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome | ribosomal protein S2 | 0.755 |
EEF1D | RPS3 | ENSP00000391944 | ENSP00000433821 | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein); Isoform 1- EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome | ribosomal protein S3 | 0.794 |
EEF1D | TPT1 | ENSP00000391944 | ENSP00000431872 | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein); Isoform 1- EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome | tumor protein, translationally-controlled 1; Involved in calcium binding and microtubule stabilization | 0.955 |
EEF1D | UBC | ENSP00000391944 | ENSP00000344818 | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein); Isoform 1- EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome | ubiquitin C | 0.978 |
PLK1 | TP53 | ENSP00000300093 | ENSP00000269305 | polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.989 |
PLK1 | TPT1 | ENSP00000300093 | ENSP00000431872 | polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] | tumor protein, translationally-controlled 1; Involved in calcium binding and microtubule stabilization | 0.970 |
PLK1 | UBC | ENSP00000300093 | ENSP00000344818 | polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] | ubiquitin C | 0.998 |
RHEB | TP53 | ENSP00000262187 | ENSP00000269305 | Ras homolog enriched in brain; Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.476 |
RHEB | TPT1 | ENSP00000262187 | ENSP00000431872 | Ras homolog enriched in brain; Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity | tumor protein, translationally-controlled 1; Involved in calcium binding and microtubule stabilization | 0.972 |
RHEB | UBC | ENSP00000262187 | ENSP00000344818 | Ras homolog enriched in brain; Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity | ubiquitin C | 0.765 |
RPL27A | EEF1D | ENSP00000346015 | ENSP00000391944 | ribosomal protein L27a | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein); Isoform 1- EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome | 0.745 |
RPL27A | RPL5 | ENSP00000346015 | ENSP00000359345 | ribosomal protein L27a | ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA | 0.999 |
RPL27A | RPS15 | ENSP00000346015 | ENSP00000467676 | ribosomal protein L27a | ribosomal protein S15 | 0.999 |
RPL27A | RPS2 | ENSP00000346015 | ENSP00000341885 | ribosomal protein L27a | ribosomal protein S2 | 0.999 |
RPL27A | RPS3 | ENSP00000346015 | ENSP00000433821 | ribosomal protein L27a | ribosomal protein S3 | 0.999 |
RPL27A | TPT1 | ENSP00000346015 | ENSP00000431872 | ribosomal protein L27a | tumor protein, translationally-controlled 1; Involved in calcium binding and microtubule stabilization | 0.941 |
RPL27A | UBC | ENSP00000346015 | ENSP00000344818 | ribosomal protein L27a | ubiquitin C | 0.993 |