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STRINGSTRING
EEF1D EEF1D PLK1 PLK1 TPT1 TPT1 RPS15 RPS15 RPL5 RPL5 TP53 TP53 RPS2 RPS2 UBC UBC RPS3 RPS3 RPL27A RPL27A RHEB RHEB
"TPT1" - tumor protein, translationally-controlled 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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[Homology]
Score
TPT1tumor protein, translationally-controlled 1; Involved in calcium binding and microtubule stabilization (172 aa)    
Predicted Functional Partners:
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) (393 aa)
        score_image   score_image   0.985
RHEB
Ras homolog enriched in brain; Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity (184 aa)
        score_image   score_image   0.972
PLK1
polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] (603 aa)
        score_image score_image score_image   0.970
RPS3
ribosomal protein S3 (243 aa)
      score_image     score_image   0.969
UBC
ubiquitin C (685 aa)
      score_image score_image   score_image   0.964
EEF1D
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein); Isoform 1- EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome (647 aa)
      score_image score_image   score_image   0.955
RPS2
ribosomal protein S2 (293 aa)
      score_image     score_image   0.945
RPL27A
ribosomal protein L27a (148 aa)
      score_image     score_image   0.941
RPS15
ribosomal protein S15 (145 aa)
      score_image     score_image   0.938
RPL5
ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA (297 aa)
      score_image     score_image   0.935
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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