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PDE10A PDE10A NUDT16 NUDT16 UPRT UPRT AMPD2 AMPD2 ENSG00000250741 ENSG00000250741 AMPD3 AMPD3 AMPD1 AMPD1 PDE4A PDE4A PDE4C PDE4C PDE4B PDE4B PDE4D PDE4D
"ENSG00000250741" - NT5C1B-RDH14 readthrough in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSG00000250741NT5C1B-RDH14 readthrough (602 aa)    
Predicted Functional Partners:
AMPD1
adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism (780 aa)
          score_image score_image   0.917
AMPD3
adenosine monophosphate deaminase 3; AMP deaminase plays a critical role in energy metabolism (776 aa)
          score_image score_image   0.910
AMPD2
adenosine monophosphate deaminase 2 (879 aa)
          score_image score_image   0.910
PDE4C
phosphodiesterase 4C, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (712 aa)
          score_image score_image   0.910
PDE4D
phosphodiesterase 4D, cAMP-specific (809 aa)
          score_image score_image   0.910
PDE4B
phosphodiesterase 4B, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents (736 aa)
          score_image score_image   0.910
PDE4A
phosphodiesterase 4A, cAMP-specific (886 aa)
          score_image score_image   0.910
NUDT16
nudix (nucleoside diphosphate linked moiety X)-type motif 16; RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5’monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and [...] (227 aa)
          score_image score_image   0.904
UPRT
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) (309 aa)
          score_image score_image   0.903
PDE10A
phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (789 aa)
          score_image score_image   0.903
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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