node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMPD1 | ENSG00000250741 | ENSP00000430075 | ENSP00000433415 | adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism | NT5C1B-RDH14 readthrough | 0.917 |
AMPD1 | NUDT16 | ENSP00000430075 | ENSP00000422375 | adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism | nudix (nucleoside diphosphate linked moiety X)-type motif 16; RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5’monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and [...] | 0.900 |
AMPD1 | PDE10A | ENSP00000430075 | ENSP00000438284 | adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism | phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate | 0.900 |
AMPD1 | PDE4A | ENSP00000430075 | ENSP00000270474 | adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism | phosphodiesterase 4A, cAMP-specific | 0.900 |
AMPD1 | PDE4B | ENSP00000430075 | ENSP00000332116 | adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism | phosphodiesterase 4B, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents | 0.900 |
AMPD1 | PDE4C | ENSP00000430075 | ENSP00000347689 | adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism | phosphodiesterase 4C, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes | 0.900 |
AMPD1 | PDE4D | ENSP00000430075 | ENSP00000345502 | adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism | phosphodiesterase 4D, cAMP-specific | 0.900 |
AMPD2 | ENSG00000250741 | ENSP00000256578 | ENSP00000433415 | adenosine monophosphate deaminase 2 | NT5C1B-RDH14 readthrough | 0.910 |
AMPD2 | NUDT16 | ENSP00000256578 | ENSP00000422375 | adenosine monophosphate deaminase 2 | nudix (nucleoside diphosphate linked moiety X)-type motif 16; RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5’monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and [...] | 0.900 |
AMPD2 | PDE10A | ENSP00000256578 | ENSP00000438284 | adenosine monophosphate deaminase 2 | phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate | 0.900 |
AMPD2 | PDE4A | ENSP00000256578 | ENSP00000270474 | adenosine monophosphate deaminase 2 | phosphodiesterase 4A, cAMP-specific | 0.900 |
AMPD2 | PDE4B | ENSP00000256578 | ENSP00000332116 | adenosine monophosphate deaminase 2 | phosphodiesterase 4B, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents | 0.900 |
AMPD2 | PDE4C | ENSP00000256578 | ENSP00000347689 | adenosine monophosphate deaminase 2 | phosphodiesterase 4C, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes | 0.900 |
AMPD2 | PDE4D | ENSP00000256578 | ENSP00000345502 | adenosine monophosphate deaminase 2 | phosphodiesterase 4D, cAMP-specific | 0.900 |
AMPD3 | ENSG00000250741 | ENSP00000379802 | ENSP00000433415 | adenosine monophosphate deaminase 3; AMP deaminase plays a critical role in energy metabolism | NT5C1B-RDH14 readthrough | 0.910 |
AMPD3 | NUDT16 | ENSP00000379802 | ENSP00000422375 | adenosine monophosphate deaminase 3; AMP deaminase plays a critical role in energy metabolism | nudix (nucleoside diphosphate linked moiety X)-type motif 16; RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5’monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and [...] | 0.900 |
AMPD3 | PDE10A | ENSP00000379802 | ENSP00000438284 | adenosine monophosphate deaminase 3; AMP deaminase plays a critical role in energy metabolism | phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate | 0.900 |
AMPD3 | PDE4A | ENSP00000379802 | ENSP00000270474 | adenosine monophosphate deaminase 3; AMP deaminase plays a critical role in energy metabolism | phosphodiesterase 4A, cAMP-specific | 0.900 |
AMPD3 | PDE4B | ENSP00000379802 | ENSP00000332116 | adenosine monophosphate deaminase 3; AMP deaminase plays a critical role in energy metabolism | phosphodiesterase 4B, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents | 0.907 |
AMPD3 | PDE4C | ENSP00000379802 | ENSP00000347689 | adenosine monophosphate deaminase 3; AMP deaminase plays a critical role in energy metabolism | phosphodiesterase 4C, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes | 0.900 |