node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C14orf93 | KANK4 | ENSP00000299088 | ENSP00000360195 | chromosome 14 open reading frame 93 | KN motif and ankyrin repeat domains 4; May be involved in the control of cytoskeleton formation by regulating actin polymerization | 0.754 |
C14orf93 | TCEB3 | ENSP00000299088 | ENSP00000395574 | chromosome 14 open reading frame 93 | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | 0.718 |
C14orf93 | TCEB3B | ENSP00000299088 | ENSP00000331302 | chromosome 14 open reading frame 93 | transcription elongation factor B polypeptide 3B (elongin A2); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | 0.600 |
C14orf93 | ZBTB44 | ENSP00000299088 | ENSP00000433457 | chromosome 14 open reading frame 93 | zinc finger and BTB domain containing 44; May be involved in transcriptional regulation (By similarity) | 0.675 |
KANK4 | C14orf93 | ENSP00000360195 | ENSP00000299088 | KN motif and ankyrin repeat domains 4; May be involved in the control of cytoskeleton formation by regulating actin polymerization | chromosome 14 open reading frame 93 | 0.754 |
KANK4 | TCEB3 | ENSP00000360195 | ENSP00000395574 | KN motif and ankyrin repeat domains 4; May be involved in the control of cytoskeleton formation by regulating actin polymerization | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | 0.655 |
KANK4 | TCEB3B | ENSP00000360195 | ENSP00000331302 | KN motif and ankyrin repeat domains 4; May be involved in the control of cytoskeleton formation by regulating actin polymerization | transcription elongation factor B polypeptide 3B (elongin A2); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | 0.604 |
KANK4 | ZBTB44 | ENSP00000360195 | ENSP00000433457 | KN motif and ankyrin repeat domains 4; May be involved in the control of cytoskeleton formation by regulating actin polymerization | zinc finger and BTB domain containing 44; May be involved in transcriptional regulation (By similarity) | 0.659 |
KDM2A | ZBTB44 | ENSP00000432786 | ENSP00000433457 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger and BTB domain containing 44; May be involved in transcriptional regulation (By similarity) | 0.501 |
POLI | ZBTB44 | ENSP00000462664 | ENSP00000433457 | polymerase (DNA directed) iota; Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5’-deoxyribose phosphate at abasic [...] | zinc finger and BTB domain containing 44; May be involved in transcriptional regulation (By similarity) | 0.549 |
RNF216 | ZBTB44 | ENSP00000374552 | ENSP00000433457 | ring finger protein 216; Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis | zinc finger and BTB domain containing 44; May be involved in transcriptional regulation (By similarity) | 0.519 |
SMYD1 | ZBTB44 | ENSP00000393453 | ENSP00000433457 | SET and MYND domain containing 1; Methylates histone H3 at ’Lys-4’ (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis | zinc finger and BTB domain containing 44; May be involved in transcriptional regulation (By similarity) | 0.562 |
TCEB3 | C14orf93 | ENSP00000395574 | ENSP00000299088 | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | chromosome 14 open reading frame 93 | 0.718 |
TCEB3 | KANK4 | ENSP00000395574 | ENSP00000360195 | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | KN motif and ankyrin repeat domains 4; May be involved in the control of cytoskeleton formation by regulating actin polymerization | 0.655 |
TCEB3 | ZBTB44 | ENSP00000395574 | ENSP00000433457 | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | zinc finger and BTB domain containing 44; May be involved in transcriptional regulation (By similarity) | 0.643 |
TCEB3B | C14orf93 | ENSP00000331302 | ENSP00000299088 | transcription elongation factor B polypeptide 3B (elongin A2); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | chromosome 14 open reading frame 93 | 0.600 |
TCEB3B | KANK4 | ENSP00000331302 | ENSP00000360195 | transcription elongation factor B polypeptide 3B (elongin A2); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | KN motif and ankyrin repeat domains 4; May be involved in the control of cytoskeleton formation by regulating actin polymerization | 0.604 |
TCEB3B | ZBTB44 | ENSP00000331302 | ENSP00000433457 | transcription elongation factor B polypeptide 3B (elongin A2); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | zinc finger and BTB domain containing 44; May be involved in transcriptional regulation (By similarity) | 0.566 |
WDFY3 | ZBTB44 | ENSP00000295888 | ENSP00000433457 | WD repeat and FYVE domain containing 3 | zinc finger and BTB domain containing 44; May be involved in transcriptional regulation (By similarity) | 0.534 |
XRN1 | ZBTB44 | ENSP00000264951 | ENSP00000433457 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger and BTB domain containing 44; May be involved in transcriptional regulation (By similarity) | 0.543 |