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EPPIN EPPIN EFHD2 EFHD2 ENSG00000249139 ENSG00000249139 EFHD1 EFHD1 TPD52L1 TPD52L1 TPD52L3 TPD52L3 TPD52L2 TPD52L2 YWHAB YWHAB TPD52 TPD52 YWHAZ YWHAZ MAP3K5 MAP3K5
"TPD52L1" - tumor protein D52-like 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
TPD52L1tumor protein D52-like 1 (204 aa)    
Predicted Functional Partners:
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in bloc [...] (246 aa)
        score_image   score_image   0.644
TPD52L3
tumor protein D52-like 3 (140 aa)
        score_image   score_image score_image 0.605
ENSG00000249139
EPPIN-WFDC6 readthrough (179 aa)
            score_image   0.601
TPD52L2
tumor protein D52-like 2 (229 aa)
        score_image   score_image score_image 0.599
EFHD1
EF-hand domain family, member D1 (239 aa)
            score_image   0.598
TPD52
tumor protein D52 (224 aa)
        score_image   score_image score_image 0.594
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide (245 aa)
        score_image   score_image   0.586
EPPIN
epididymal peptidase inhibitor; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (179 aa)
            score_image   0.583
MAP3K5
mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] (1374 aa)
        score_image   score_image   0.579
EFHD2
EF-hand domain family, member D2; May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance (By similarity) (240 aa)
            score_image   0.576
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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