node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KCNAB1 | KCNAB2 | ENSP00000419952 | ENSP00000367323 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | 0.902 |
KCNAB1 | KCNAB3 | ENSP00000419952 | ENSP00000302719 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, shaker-related subfamily, beta member 3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5 | 0.903 |
KCNAB1 | KCNC3 | ENSP00000419952 | ENSP00000434241 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, Shaw-related subfamily, member 3; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient | 0.944 |
KCNAB1 | KCND2 | ENSP00000419952 | ENSP00000333496 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | 0.965 |
KCNAB1 | KCNH1 | ENSP00000419952 | ENSP00000271751 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | 0.924 |
KCNAB1 | KCNH2 | ENSP00000419952 | ENSP00000262186 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 | 0.942 |
KCNAB1 | KCNH5 | ENSP00000419952 | ENSP00000321427 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 5; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly | 0.920 |
KCNAB1 | KCNH8 | ENSP00000419952 | ENSP00000328813 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 8; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly | 0.927 |
KCNAB1 | KCNQ2 | ENSP00000419952 | ENSP00000352035 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, KQT-like subfamily, member 2 | 0.940 |
KCNAB1 | KCNQ3 | ENSP00000419952 | ENSP00000373648 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, KQT-like subfamily, member 3; Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs | 0.939 |
KCNAB2 | KCNAB1 | ENSP00000367323 | ENSP00000419952 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | 0.902 |
KCNAB2 | KCNAB3 | ENSP00000367323 | ENSP00000302719 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, shaker-related subfamily, beta member 3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5 | 0.903 |
KCNAB2 | KCNC3 | ENSP00000367323 | ENSP00000434241 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, Shaw-related subfamily, member 3; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient | 0.943 |
KCNAB2 | KCND2 | ENSP00000367323 | ENSP00000333496 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | 0.956 |
KCNAB2 | KCNH1 | ENSP00000367323 | ENSP00000271751 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | 0.929 |
KCNAB2 | KCNH2 | ENSP00000367323 | ENSP00000262186 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 | 0.933 |
KCNAB2 | KCNH5 | ENSP00000367323 | ENSP00000321427 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, subfamily H (eag-related), member 5; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly | 0.928 |
KCNAB2 | KCNH8 | ENSP00000367323 | ENSP00000328813 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, subfamily H (eag-related), member 8; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly | 0.933 |
KCNAB2 | KCNQ2 | ENSP00000367323 | ENSP00000352035 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, KQT-like subfamily, member 2 | 0.940 |
KCNAB2 | KCNQ3 | ENSP00000367323 | ENSP00000373648 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | potassium voltage-gated channel, KQT-like subfamily, member 3; Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs | 0.938 |