SLC6A5 protein (Homo sapiens) - STRING network view

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SLC6A5

solute carrier family 6 (neurotransmitter transporter, glycine), member 5; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (797 aa)

Predicted Functional Partners:

GLRA1

0.833

DPYSL5

0.803

GLRB

0.770

GARS

0.755

SLC32A1

0.737

GAD1

0.733

GPHN

0.720

GAD2

0.674

SLC17A6

0.660

STX1A

0.633

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DPYSL5	GLRA1	ENSP00000288699	ENSP00000411593	dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth	glycine receptor, alpha 1; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)	0.748
DPYSL5	SLC6A5	ENSP00000288699	ENSP00000434364	dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth	solute carrier family 6 (neurotransmitter transporter, glycine), member 5; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses	0.803
GAD1	GAD2	ENSP00000350928	ENSP00000259271	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	0.919
GAD1	GPHN	ENSP00000350928	ENSP00000417901	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released	0.534
GAD1	SLC17A6	ENSP00000350928	ENSP00000263160	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate	0.795
GAD1	SLC32A1	ENSP00000350928	ENSP00000217420	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	solute carrier family 32 (GABA vesicular transporter), member 1; Involved in the uptake of GABA and glycine into the synaptic vesicles	0.932
GAD1	SLC6A5	ENSP00000350928	ENSP00000434364	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	solute carrier family 6 (neurotransmitter transporter, glycine), member 5; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses	0.733
GAD2	GAD1	ENSP00000259271	ENSP00000350928	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	0.919
GAD2	GLRA1	ENSP00000259271	ENSP00000411593	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	glycine receptor, alpha 1; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)	0.584
GAD2	GLRB	ENSP00000259271	ENSP00000264428	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	glycine receptor, beta; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)	0.457
GAD2	GPHN	ENSP00000259271	ENSP00000417901	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released	0.608
GAD2	SLC17A6	ENSP00000259271	ENSP00000263160	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate	0.730
GAD2	SLC32A1	ENSP00000259271	ENSP00000217420	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	solute carrier family 32 (GABA vesicular transporter), member 1; Involved in the uptake of GABA and glycine into the synaptic vesicles	0.965
GAD2	SLC6A5	ENSP00000259271	ENSP00000434364	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	solute carrier family 6 (neurotransmitter transporter, glycine), member 5; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses	0.674
GAD2	STX1A	ENSP00000259271	ENSP00000222812	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	syntaxin 1A (brain)	0.477
GARS	GLRA1	ENSP00000373918	ENSP00000411593	glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs	glycine receptor, alpha 1; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)	0.637
GARS	GPHN	ENSP00000373918	ENSP00000417901	glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs	gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released	0.973
GARS	SLC32A1	ENSP00000373918	ENSP00000217420	glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs	solute carrier family 32 (GABA vesicular transporter), member 1; Involved in the uptake of GABA and glycine into the synaptic vesicles	0.581
GARS	SLC6A5	ENSP00000373918	ENSP00000434364	glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs	solute carrier family 6 (neurotransmitter transporter, glycine), member 5; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses	0.755
GLRA1	DPYSL5	ENSP00000411593	ENSP00000288699	glycine receptor, alpha 1; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)	dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth	0.748

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