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AAED1 AAED1 CDKN1A CDKN1A ATP5C1 ATP5C1 ATP5B ATP5B SLC25A3 SLC25A3 ACER3 ACER3 ASAH2B ASAH2B CERS3 CERS3 ASAH1 ASAH1 ASAH2 ASAH2 CERS6 CERS6
"ACER3" - alkaline ceramidase 3 in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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Score
ACER3alkaline ceramidase 3; Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity (267 aa)    
Predicted Functional Partners:
ASAH2
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabo [...] (780 aa)
            score_image   0.923
ASAH2B
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B (165 aa)
            score_image   0.857
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (164 aa)
            score_image   0.803
SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) (362 aa)
      score_image     score_image   0.770
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid (411 aa)
            score_image   0.759
ATP5C1
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is cou [...] (298 aa)
            score_image   0.751
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is couple [...] (529 aa)
            score_image   0.749
CERS3
ceramide synthase 3; May be involved in sphingolipid synthesis or its regulation (By similarity) (383 aa)
        score_image   score_image   0.636
CERS6
ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation (By similarity) (384 aa)
        score_image   score_image   0.632
AAED1
AhpC/TSA antioxidant enzyme domain containing 1 (226 aa)
            score_image   0.628
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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