ENSG00000254469 protein (Homo sapiens)

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ENSG00000254469

Putative short transient receptor potential channel 2-like protein (206 aa)

Predicted Functional Partners:

ITPR3

0.815

TRPC6

0.806

ASPH

0.795

TRPC3

0.755

TRPC7

0.750

TRPC1

0.738

TRPC4

0.734

TRPC5

0.734

RNF121

0.705

ITPR2

0.677

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPH	ENSG00000254469	ENSP00000368767	ENSP00000434508	aspartate beta-hydroxylase	Putative short transient receptor potential channel 2-like protein	0.795
ASPH	TRPC1	ENSP00000368767	ENSP00000273482	aspartate beta-hydroxylase	transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion	0.416
ENSG00000254469	ASPH	ENSP00000434508	ENSP00000368767	Putative short transient receptor potential channel 2-like protein	aspartate beta-hydroxylase	0.795
ENSG00000254469	ITPR2	ENSP00000434508	ENSP00000370744	Putative short transient receptor potential channel 2-like protein	inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity)	0.677
ENSG00000254469	ITPR3	ENSP00000434508	ENSP00000363435	Putative short transient receptor potential channel 2-like protein	inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium	0.815
ENSG00000254469	RNF121	ENSP00000434508	ENSP00000354571	Putative short transient receptor potential channel 2-like protein	ring finger protein 121	0.705
ENSG00000254469	TRPC1	ENSP00000434508	ENSP00000273482	Putative short transient receptor potential channel 2-like protein	transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion	0.738
ENSG00000254469	TRPC3	ENSP00000434508	ENSP00000368966	Putative short transient receptor potential channel 2-like protein	transient receptor potential cation channel, subfamily C, member 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion	0.755
ENSG00000254469	TRPC4	ENSP00000434508	ENSP00000369003	Putative short transient receptor potential channel 2-like protein	transient receptor potential cation channel, subfamily C, member 4	0.734
ENSG00000254469	TRPC5	ENSP00000434508	ENSP00000262839	Putative short transient receptor potential channel 2-like protein	transient receptor potential cation channel, subfamily C, member 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion	0.734
ENSG00000254469	TRPC6	ENSP00000434508	ENSP00000340913	Putative short transient receptor potential channel 2-like protein	transient receptor potential cation channel, subfamily C, member 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion	0.806
ENSG00000254469	TRPC7	ENSP00000434508	ENSP00000426070	Putative short transient receptor potential channel 2-like protein	transient receptor potential cation channel, subfamily C, member 7; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion	0.750
ITPR2	ENSG00000254469	ENSP00000370744	ENSP00000434508	inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity)	Putative short transient receptor potential channel 2-like protein	0.677
ITPR2	ITPR3	ENSP00000370744	ENSP00000363435	inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity)	inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium	0.902
ITPR2	TRPC1	ENSP00000370744	ENSP00000273482	inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity)	transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion	0.973
ITPR2	TRPC3	ENSP00000370744	ENSP00000368966	inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity)	transient receptor potential cation channel, subfamily C, member 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion	0.892
ITPR2	TRPC4	ENSP00000370744	ENSP00000369003	inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity)	transient receptor potential cation channel, subfamily C, member 4	0.720
ITPR3	ENSG00000254469	ENSP00000363435	ENSP00000434508	inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium	Putative short transient receptor potential channel 2-like protein	0.815
ITPR3	ITPR2	ENSP00000363435	ENSP00000370744	inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium	inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity)	0.902
ITPR3	TRPC1	ENSP00000363435	ENSP00000273482	inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium	transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion	0.999

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