node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASPH | ENSG00000254469 | ENSP00000368767 | ENSP00000434508 | aspartate beta-hydroxylase | Putative short transient receptor potential channel 2-like protein | 0.795 |
ASPH | TRPC1 | ENSP00000368767 | ENSP00000273482 | aspartate beta-hydroxylase | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | 0.416 |
ENSG00000254469 | ASPH | ENSP00000434508 | ENSP00000368767 | Putative short transient receptor potential channel 2-like protein | aspartate beta-hydroxylase | 0.795 |
ENSG00000254469 | ITPR2 | ENSP00000434508 | ENSP00000370744 | Putative short transient receptor potential channel 2-like protein | inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity) | 0.677 |
ENSG00000254469 | ITPR3 | ENSP00000434508 | ENSP00000363435 | Putative short transient receptor potential channel 2-like protein | inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium | 0.815 |
ENSG00000254469 | RNF121 | ENSP00000434508 | ENSP00000354571 | Putative short transient receptor potential channel 2-like protein | ring finger protein 121 | 0.705 |
ENSG00000254469 | TRPC1 | ENSP00000434508 | ENSP00000273482 | Putative short transient receptor potential channel 2-like protein | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | 0.738 |
ENSG00000254469 | TRPC3 | ENSP00000434508 | ENSP00000368966 | Putative short transient receptor potential channel 2-like protein | transient receptor potential cation channel, subfamily C, member 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion | 0.755 |
ENSG00000254469 | TRPC4 | ENSP00000434508 | ENSP00000369003 | Putative short transient receptor potential channel 2-like protein | transient receptor potential cation channel, subfamily C, member 4 | 0.734 |
ENSG00000254469 | TRPC5 | ENSP00000434508 | ENSP00000262839 | Putative short transient receptor potential channel 2-like protein | transient receptor potential cation channel, subfamily C, member 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion | 0.734 |
ENSG00000254469 | TRPC6 | ENSP00000434508 | ENSP00000340913 | Putative short transient receptor potential channel 2-like protein | transient receptor potential cation channel, subfamily C, member 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion | 0.806 |
ENSG00000254469 | TRPC7 | ENSP00000434508 | ENSP00000426070 | Putative short transient receptor potential channel 2-like protein | transient receptor potential cation channel, subfamily C, member 7; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion | 0.750 |
ITPR2 | ENSG00000254469 | ENSP00000370744 | ENSP00000434508 | inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity) | Putative short transient receptor potential channel 2-like protein | 0.677 |
ITPR2 | ITPR3 | ENSP00000370744 | ENSP00000363435 | inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity) | inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium | 0.902 |
ITPR2 | TRPC1 | ENSP00000370744 | ENSP00000273482 | inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity) | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | 0.973 |
ITPR2 | TRPC3 | ENSP00000370744 | ENSP00000368966 | inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity) | transient receptor potential cation channel, subfamily C, member 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion | 0.892 |
ITPR2 | TRPC4 | ENSP00000370744 | ENSP00000369003 | inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity) | transient receptor potential cation channel, subfamily C, member 4 | 0.720 |
ITPR3 | ENSG00000254469 | ENSP00000363435 | ENSP00000434508 | inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium | Putative short transient receptor potential channel 2-like protein | 0.815 |
ITPR3 | ITPR2 | ENSP00000363435 | ENSP00000370744 | inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium | inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity) | 0.902 |
ITPR3 | TRPC1 | ENSP00000363435 | ENSP00000273482 | inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | 0.999 |