node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCBL1 | TXNRD1 | ENSP00000302227 | ENSP00000434516 | cysteine conjugate-beta lyase, cytoplasmic; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond | thioredoxin reductase 1 | 0.918 |
CCBL2 | TXNRD1 | ENSP00000260508 | ENSP00000434516 | cysteine conjugate-beta lyase 2 | thioredoxin reductase 1 | 0.918 |
CCBL2 | UBC | ENSP00000260508 | ENSP00000344818 | cysteine conjugate-beta lyase 2 | ubiquitin C | 0.796 |
CREBBP | NCOA2 | ENSP00000262367 | ENSP00000399968 | CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 | nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues | 0.999 |
CREBBP | TXNRD1 | ENSP00000262367 | ENSP00000434516 | CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 | thioredoxin reductase 1 | 0.916 |
CREBBP | UBC | ENSP00000262367 | ENSP00000344818 | CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 | ubiquitin C | 0.884 |
NCOA2 | CREBBP | ENSP00000399968 | ENSP00000262367 | nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues | CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 | 0.999 |
NCOA2 | TXNRD1 | ENSP00000399968 | ENSP00000434516 | nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues | thioredoxin reductase 1 | 0.955 |
NCOA2 | UBC | ENSP00000399968 | ENSP00000344818 | nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues | ubiquitin C | 0.620 |
RRM1 | RRM2 | ENSP00000300738 | ENSP00000353770 | ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) | ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling | 0.999 |
RRM1 | TXN | ENSP00000300738 | ENSP00000363641 | ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) | thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates A [...] | 0.936 |
RRM1 | TXNRD1 | ENSP00000300738 | ENSP00000434516 | ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) | thioredoxin reductase 1 | 0.927 |
RRM1 | UBC | ENSP00000300738 | ENSP00000344818 | ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) | ubiquitin C | 0.989 |
RRM2 | RRM1 | ENSP00000353770 | ENSP00000300738 | ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling | ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) | 0.999 |
RRM2 | TXN | ENSP00000353770 | ENSP00000363641 | ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling | thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates A [...] | 0.962 |
RRM2 | TXNRD1 | ENSP00000353770 | ENSP00000434516 | ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling | thioredoxin reductase 1 | 0.937 |
RRM2 | UBC | ENSP00000353770 | ENSP00000344818 | ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling | ubiquitin C | 0.962 |
SEPHS1 | TXNRD1 | ENSP00000367893 | ENSP00000434516 | selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP | thioredoxin reductase 1 | 0.929 |
SEPHS1 | UBC | ENSP00000367893 | ENSP00000344818 | selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP | ubiquitin C | 0.620 |
SEPHS2 | TXNRD1 | ENSP00000426234 | ENSP00000434516 | selenophosphate synthetase 2; Synthesizes selenophosphate from selenide and ATP | thioredoxin reductase 1 | 0.953 |