USP50 protein (Homo sapiens) - STRING network view

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Score

USP50

ubiquitin specific peptidase 50; Has no peptidase activity (334 aa)

Predicted Functional Partners:

HUWE1

0.836

CHMP3

0.765

ENSG00000249884

0.765

UMPS

0.757

USP13

0.747

SLC1A5

0.740

SRPRB

0.740

ACADM

0.740

SLC25A13

0.740

DYNC2H1

0.740

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACADM	USP50	ENSP00000409612	ENSP00000434676	acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16	ubiquitin specific peptidase 50; Has no peptidase activity	0.740
CHMP3	USP50	ENSP00000405575	ENSP00000434676	charged multivesicular body protein 3	ubiquitin specific peptidase 50; Has no peptidase activity	0.765
DYNC2H1	USP50	ENSP00000381167	ENSP00000434676	dynein, cytoplasmic 2, heavy chain 1	ubiquitin specific peptidase 50; Has no peptidase activity	0.740
ENSG00000249884	USP50	ENSP00000392995	ENSP00000434676	RNF103-CHMP3 readthrough	ubiquitin specific peptidase 50; Has no peptidase activity	0.765
HUWE1	USP50	ENSP00000262854	ENSP00000434676	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	ubiquitin specific peptidase 50; Has no peptidase activity	0.836
SLC1A5	USP50	ENSP00000444408	ENSP00000434676	solute carrier family 1 (neutral amino acid transporter), member 5	ubiquitin specific peptidase 50; Has no peptidase activity	0.740
SLC25A13	USP50	ENSP00000400101	ENSP00000434676	solute carrier family 25 (aspartate/glutamate carrier), member 13; Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle	ubiquitin specific peptidase 50; Has no peptidase activity	0.740
SRPRB	USP50	ENSP00000418401	ENSP00000434676	signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity)	ubiquitin specific peptidase 50; Has no peptidase activity	0.740
UMPS	USP50	ENSP00000232607	ENSP00000434676	uridine monophosphate synthetase	ubiquitin specific peptidase 50; Has no peptidase activity	0.757
USP13	USP50	ENSP00000263966	ENSP00000434676	ubiquitin specific peptidase 13 (isopeptidase T-3); Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regula [...]	ubiquitin specific peptidase 50; Has no peptidase activity	0.747
USP50	ACADM	ENSP00000434676	ENSP00000409612	ubiquitin specific peptidase 50; Has no peptidase activity	acyl-CoA dehydrogenase, C-4 to C-12 straight chain; This enzyme is specific for acyl chain lengths of 4 to 16	0.740
USP50	CHMP3	ENSP00000434676	ENSP00000405575	ubiquitin specific peptidase 50; Has no peptidase activity	charged multivesicular body protein 3	0.765
USP50	DYNC2H1	ENSP00000434676	ENSP00000381167	ubiquitin specific peptidase 50; Has no peptidase activity	dynein, cytoplasmic 2, heavy chain 1	0.740
USP50	ENSG00000249884	ENSP00000434676	ENSP00000392995	ubiquitin specific peptidase 50; Has no peptidase activity	RNF103-CHMP3 readthrough	0.765
USP50	HUWE1	ENSP00000434676	ENSP00000262854	ubiquitin specific peptidase 50; Has no peptidase activity	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	0.836
USP50	SLC1A5	ENSP00000434676	ENSP00000444408	ubiquitin specific peptidase 50; Has no peptidase activity	solute carrier family 1 (neutral amino acid transporter), member 5	0.740
USP50	SLC25A13	ENSP00000434676	ENSP00000400101	ubiquitin specific peptidase 50; Has no peptidase activity	solute carrier family 25 (aspartate/glutamate carrier), member 13; Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle	0.740
USP50	SRPRB	ENSP00000434676	ENSP00000418401	ubiquitin specific peptidase 50; Has no peptidase activity	signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity)	0.740
USP50	UMPS	ENSP00000434676	ENSP00000232607	ubiquitin specific peptidase 50; Has no peptidase activity	uridine monophosphate synthetase	0.757
USP50	USP13	ENSP00000434676	ENSP00000263966	ubiquitin specific peptidase 50; Has no peptidase activity	ubiquitin specific peptidase 13 (isopeptidase T-3); Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regula [...]	0.747

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