node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATAD5 | RAD52 | ENSP00000313171 | ENSP00000351284 | ATPase family, AAA domain containing 5; Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis | RAD52 homolog (S. cerevisiae); Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase | 0.843 |
ATAD5 | RNF170 | ENSP00000313171 | ENSP00000434797 | ATPase family, AAA domain containing 5; Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis | ring finger protein 170 | 0.582 |
ATAD5 | TTF2 | ENSP00000313171 | ENSP00000358478 | ATPase family, AAA domain containing 5; Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis | transcription termination factor, RNA polymerase II; DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing | 0.540 |
ATAD5 | UBC | ENSP00000313171 | ENSP00000344818 | ATPase family, AAA domain containing 5; Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis | ubiquitin C | 0.620 |
ERLIN1 | ERLIN2 | ENSP00000384900 | ENSP00000276461 | ER lipid raft associated 1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | 0.978 |
ERLIN1 | RNF122 | ENSP00000384900 | ENSP00000256257 | ER lipid raft associated 1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) | ring finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability | 0.510 |
ERLIN1 | RNF170 | ENSP00000384900 | ENSP00000434797 | ER lipid raft associated 1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) | ring finger protein 170 | 0.635 |
ERLIN1 | UBC | ENSP00000384900 | ENSP00000344818 | ER lipid raft associated 1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) | ubiquitin C | 0.858 |
ERLIN2 | ERLIN1 | ENSP00000276461 | ENSP00000384900 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | ER lipid raft associated 1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) | 0.978 |
ERLIN2 | RNF122 | ENSP00000276461 | ENSP00000256257 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | ring finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability | 0.492 |
ERLIN2 | RNF170 | ENSP00000276461 | ENSP00000434797 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | ring finger protein 170 | 0.610 |
ERLIN2 | UBC | ENSP00000276461 | ENSP00000344818 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | ubiquitin C | 0.919 |
NRG1 | RNF170 | ENSP00000349275 | ENSP00000434797 | neuregulin 1 | ring finger protein 170 | 0.590 |
PSMA6 | RNF170 | ENSP00000261479 | ENSP00000434797 | proteasome (prosome, macropain) subunit, alpha type, 6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity) | ring finger protein 170 | 0.576 |
PSMA6 | UBC | ENSP00000261479 | ENSP00000344818 | proteasome (prosome, macropain) subunit, alpha type, 6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity) | ubiquitin C | 0.999 |
RAD52 | ATAD5 | ENSP00000351284 | ENSP00000313171 | RAD52 homolog (S. cerevisiae); Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase | ATPase family, AAA domain containing 5; Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis | 0.843 |
RAD52 | RNF170 | ENSP00000351284 | ENSP00000434797 | RAD52 homolog (S. cerevisiae); Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase | ring finger protein 170 | 0.687 |
RNF122 | ERLIN1 | ENSP00000256257 | ENSP00000384900 | ring finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability | ER lipid raft associated 1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) | 0.510 |
RNF122 | ERLIN2 | ENSP00000256257 | ENSP00000276461 | ring finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | 0.492 |
RNF122 | RNF170 | ENSP00000256257 | ENSP00000434797 | ring finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability | ring finger protein 170 | 0.610 |