| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CASK | EPHA5 | ENSP00000367408 | ENSP00000273854 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | EPH receptor A5; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the deve [...] | 0.548 |
| CASK | ITK | ENSP00000367408 | ENSP00000398655 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | IL2-inducible T-cell kinase; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activ [...] | 0.508 |
| CASK | KIRREL3 | ENSP00000367408 | ENSP00000435466 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | 0.822 |
| CASK | NPHS1 | ENSP00000367408 | ENSP00000368190 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | nephrosis 1, congenital, Finnish type (nephrin); Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity) | 0.927 |
| CASK | TANC1 | ENSP00000367408 | ENSP00000263635 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1; May be a scaffold component in the postsynaptic density (By similarity) | 0.573 |
| CDH15 | KIRREL3 | ENSP00000289746 | ENSP00000435466 | cadherin 15, type 1, M-cadherin (myotubule); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | 0.744 |
| EPHA5 | CASK | ENSP00000273854 | ENSP00000367408 | EPH receptor A5; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the deve [...] | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.548 |
| EPHA5 | KIRREL2 | ENSP00000273854 | ENSP00000353331 | EPH receptor A5; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the deve [...] | kin of IRRE like 2 (Drosophila) | 0.578 |
| EPHA5 | KIRREL3 | ENSP00000273854 | ENSP00000435466 | EPH receptor A5; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the deve [...] | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | 0.653 |
| ITK | CASK | ENSP00000398655 | ENSP00000367408 | IL2-inducible T-cell kinase; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activ [...] | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.508 |
| ITK | KIRREL2 | ENSP00000398655 | ENSP00000353331 | IL2-inducible T-cell kinase; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activ [...] | kin of IRRE like 2 (Drosophila) | 0.744 |
| ITK | KIRREL3 | ENSP00000398655 | ENSP00000435466 | IL2-inducible T-cell kinase; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activ [...] | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | 0.681 |
| ITK | PDZK1 | ENSP00000398655 | ENSP00000342143 | IL2-inducible T-cell kinase; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activ [...] | PDZ domain containing 1 | 0.742 |
| KIRREL2 | EPHA5 | ENSP00000353331 | ENSP00000273854 | kin of IRRE like 2 (Drosophila) | EPH receptor A5; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the deve [...] | 0.578 |
| KIRREL2 | ITK | ENSP00000353331 | ENSP00000398655 | kin of IRRE like 2 (Drosophila) | IL2-inducible T-cell kinase; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activ [...] | 0.744 |
| KIRREL2 | KIRREL3 | ENSP00000353331 | ENSP00000435466 | kin of IRRE like 2 (Drosophila) | kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) | 0.909 |
| KIRREL2 | NPHS1 | ENSP00000353331 | ENSP00000368190 | kin of IRRE like 2 (Drosophila) | nephrosis 1, congenital, Finnish type (nephrin); Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity) | 0.853 |
| KIRREL2 | NPHS2 | ENSP00000353331 | ENSP00000356587 | kin of IRRE like 2 (Drosophila) | nephrosis 2, idiopathic, steroid-resistant (podocin); Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton | 0.862 |
| KIRREL2 | PDZK1 | ENSP00000353331 | ENSP00000342143 | kin of IRRE like 2 (Drosophila) | PDZ domain containing 1 | 0.817 |
| KIRREL2 | TANC1 | ENSP00000353331 | ENSP00000263635 | kin of IRRE like 2 (Drosophila) | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1; May be a scaffold component in the postsynaptic density (By similarity) | 0.749 |
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