node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASP3 | CASP6 | ENSP00000311032 | ENSP00000265164 | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death | 0.994 |
CASP3 | CASP7 | ENSP00000311032 | ENSP00000358327 | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | caspase 7, apoptosis-related cysteine peptidase | 0.933 |
CASP3 | CASP8 | ENSP00000311032 | ENSP00000351273 | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | caspase 8, apoptosis-related cysteine peptidase | 0.998 |
CASP3 | NUCB2 | ENSP00000311032 | ENSP00000436455 | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | nucleobindin 2; Calcium-binding protein. May have a role in calcium homeostasis | 0.567 |
CASP3 | UBC | ENSP00000311032 | ENSP00000344818 | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | ubiquitin C | 0.920 |
CASP6 | CASP3 | ENSP00000265164 | ENSP00000311032 | caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | 0.994 |
CASP6 | CASP7 | ENSP00000265164 | ENSP00000358327 | caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death | caspase 7, apoptosis-related cysteine peptidase | 0.407 |
CASP6 | CASP8 | ENSP00000265164 | ENSP00000351273 | caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death | caspase 8, apoptosis-related cysteine peptidase | 0.992 |
CASP6 | NUCB2 | ENSP00000265164 | ENSP00000436455 | caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death | nucleobindin 2; Calcium-binding protein. May have a role in calcium homeostasis | 0.569 |
CASP6 | UBC | ENSP00000265164 | ENSP00000344818 | caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death | ubiquitin C | 0.811 |
CASP7 | CASP3 | ENSP00000358327 | ENSP00000311032 | caspase 7, apoptosis-related cysteine peptidase | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | 0.933 |
CASP7 | CASP6 | ENSP00000358327 | ENSP00000265164 | caspase 7, apoptosis-related cysteine peptidase | caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death | 0.407 |
CASP7 | CASP8 | ENSP00000358327 | ENSP00000351273 | caspase 7, apoptosis-related cysteine peptidase | caspase 8, apoptosis-related cysteine peptidase | 0.983 |
CASP7 | NUCB2 | ENSP00000358327 | ENSP00000436455 | caspase 7, apoptosis-related cysteine peptidase | nucleobindin 2; Calcium-binding protein. May have a role in calcium homeostasis | 0.567 |
CASP7 | UBC | ENSP00000358327 | ENSP00000344818 | caspase 7, apoptosis-related cysteine peptidase | ubiquitin C | 0.869 |
CASP8 | CASP3 | ENSP00000351273 | ENSP00000311032 | caspase 8, apoptosis-related cysteine peptidase | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | 0.998 |
CASP8 | CASP6 | ENSP00000351273 | ENSP00000265164 | caspase 8, apoptosis-related cysteine peptidase | caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death | 0.992 |
CASP8 | CASP7 | ENSP00000351273 | ENSP00000358327 | caspase 8, apoptosis-related cysteine peptidase | caspase 7, apoptosis-related cysteine peptidase | 0.983 |
CASP8 | NUCB2 | ENSP00000351273 | ENSP00000436455 | caspase 8, apoptosis-related cysteine peptidase | nucleobindin 2; Calcium-binding protein. May have a role in calcium homeostasis | 0.567 |
CASP8 | UBC | ENSP00000351273 | ENSP00000344818 | caspase 8, apoptosis-related cysteine peptidase | ubiquitin C | 0.987 |