node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | CS | ENSP00000253792 | ENSP00000342056 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | citrate synthase | 0.955 |
ACLY | FH | ENSP00000253792 | ENSP00000355518 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | fumarate hydratase; Also acts as a tumor suppressor | 0.941 |
ACLY | GOT1 | ENSP00000253792 | ENSP00000359539 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.597 |
ACLY | GOT2 | ENSP00000253792 | ENSP00000245206 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.593 |
ACLY | MDH1 | ENSP00000253792 | ENSP00000438144 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | malate dehydrogenase 1, NAD (soluble) | 0.977 |
ACLY | MDH2 | ENSP00000253792 | ENSP00000327070 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | malate dehydrogenase 2, NAD (mitochondrial) | 0.978 |
ACLY | ME1 | ENSP00000253792 | ENSP00000358719 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | malic enzyme 1, NADP(+)-dependent, cytosolic | 0.878 |
ACLY | ME2 | ENSP00000253792 | ENSP00000321070 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | malic enzyme 2, NAD(+)-dependent, mitochondrial | 0.868 |
ACLY | ME3 | ENSP00000253792 | ENSP00000352657 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | malic enzyme 3, NADP(+)-dependent, mitochondrial | 0.890 |
ACLY | PGM1 | ENSP00000253792 | ENSP00000360124 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | phosphoglucomutase 1 | 0.483 |
CS | ACLY | ENSP00000342056 | ENSP00000253792 | citrate synthase | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.955 |
CS | FH | ENSP00000342056 | ENSP00000355518 | citrate synthase | fumarate hydratase; Also acts as a tumor suppressor | 0.985 |
CS | GOT1 | ENSP00000342056 | ENSP00000359539 | citrate synthase | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.890 |
CS | GOT2 | ENSP00000342056 | ENSP00000245206 | citrate synthase | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.940 |
CS | MDH1 | ENSP00000342056 | ENSP00000438144 | citrate synthase | malate dehydrogenase 1, NAD (soluble) | 0.987 |
CS | MDH2 | ENSP00000342056 | ENSP00000327070 | citrate synthase | malate dehydrogenase 2, NAD (mitochondrial) | 0.996 |
CS | ME1 | ENSP00000342056 | ENSP00000358719 | citrate synthase | malic enzyme 1, NADP(+)-dependent, cytosolic | 0.895 |
CS | ME2 | ENSP00000342056 | ENSP00000321070 | citrate synthase | malic enzyme 2, NAD(+)-dependent, mitochondrial | 0.885 |
CS | ME3 | ENSP00000342056 | ENSP00000352657 | citrate synthase | malic enzyme 3, NADP(+)-dependent, mitochondrial | 0.904 |
CS | PGM1 | ENSP00000342056 | ENSP00000360124 | citrate synthase | phosphoglucomutase 1 | 0.461 |