Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | MTRNR2L1 | MT-RNR2-like 1; Plays a role as a neuroprotective and antiapoptotic factor (By similarity) (24 aa) | ||||||||||||
Predicted Functional Partners:
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 | MTRNR2L3 | MT-RNR2-like 3; Plays a role as a neuroprotective and antiapoptotic factor (By similarity) (24 aa) |
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0.815 | ||||||||||
 | FAM81B | family with sequence similarity 81, member B (452 aa) |
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0.807 | ||||||||||
 | C17orf51 | chromosome 17 open reading frame 51 (221 aa) |
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0.725 | ||||||||||
 | CDRT15L2 | CMT1A duplicated region transcript 15-like 2 (281 aa) |
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0.725 | ||||||||||
 | CCDC144NL | coiled-coil domain containing 144 family, N-terminal like (221 aa) |
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0.725 | ||||||||||
 | LGALS9B | lectin, galactoside-binding, soluble, 9B; Binds galactosides (By similarity) (355 aa) |
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0.725 | ||||||||||
 | UBC | ubiquitin C (685 aa) |
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0.576 | ||||||||||
 | TRIM2 | tripartite motif containing 2; UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11 (By similarity). Plays a neuroprotective function (By similarity). May play a role in neuronal rapid ischemic tolerance (By similarity) (771 aa) |
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0.576 | ||||||||||
 | TRIM11 | tripartite motif containing 11; E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation path [...] (468 aa) |
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0.576 | ||||||||||
 | PPA1 | pyrophosphatase (inorganic) 1 (289 aa) |
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0.569 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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