| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHERP | HRH1 | ENSP00000439856 | ENSP00000380247 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | histamine receptor H1; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system | 0.702 |
| CHERP | RBM7 | ENSP00000439856 | ENSP00000439918 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | 0.702 |
| CHERP | SF3B2 | ENSP00000439856 | ENSP00000318861 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | splicing factor 3b, subunit 2, 145kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron | 0.617 |
| HAUS8 | RBM7 | ENSP00000253669 | ENSP00000439918 | HAUS augmin-like complex, subunit 8; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | 0.705 |
| HRH1 | CHERP | ENSP00000380247 | ENSP00000439856 | histamine receptor H1; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | 0.702 |
| HRH1 | RBM7 | ENSP00000380247 | ENSP00000439918 | histamine receptor H1; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | 0.749 |
| KHDRBS1 | RBM7 | ENSP00000313829 | ENSP00000439918 | KH domain containing, RNA binding, signal transduction associated 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA n [...] | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | 0.763 |
| KHDRBS1 | SRSF3 | ENSP00000313829 | ENSP00000362820 | KH domain containing, RNA binding, signal transduction associated 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA n [...] | serine/arginine-rich splicing factor 3; May be involved in RNA processing in relation with cellular proliferation and/or maturation | 0.494 |
| PPP2R1A | RBM7 | ENSP00000324804 | ENSP00000439918 | protein phosphatase 2, regulatory subunit A, alpha; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | 0.731 |
| PPP2R1A | ZCCHC8 | ENSP00000324804 | ENSP00000337313 | protein phosphatase 2, regulatory subunit A, alpha; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis | zinc finger, CCHC domain containing 8; May be involved in pre-mRNA splicing | 0.731 |
| RBM14-RBM4 | RBM7 | ENSP00000425446 | ENSP00000439918 | RBM14-RBM4 readthrough; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5’-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activatio [...] | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | 0.712 |
| RBM4 | RBM7 | ENSP00000309166 | ENSP00000439918 | RNA binding motif protein 4; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5’-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational acti [...] | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | 0.731 |
| RBM7 | CHERP | ENSP00000439918 | ENSP00000439856 | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | 0.702 |
| RBM7 | HAUS8 | ENSP00000439918 | ENSP00000253669 | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | HAUS augmin-like complex, subunit 8; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex | 0.705 |
| RBM7 | HRH1 | ENSP00000439918 | ENSP00000380247 | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | histamine receptor H1; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system | 0.749 |
| RBM7 | KHDRBS1 | ENSP00000439918 | ENSP00000313829 | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | KH domain containing, RNA binding, signal transduction associated 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA n [...] | 0.763 |
| RBM7 | PPP2R1A | ENSP00000439918 | ENSP00000324804 | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | protein phosphatase 2, regulatory subunit A, alpha; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis | 0.731 |
| RBM7 | RBM14-RBM4 | ENSP00000439918 | ENSP00000425446 | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | RBM14-RBM4 readthrough; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5’-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activatio [...] | 0.712 |
| RBM7 | RBM4 | ENSP00000439918 | ENSP00000309166 | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | RNA binding motif protein 4; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5’-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational acti [...] | 0.731 |
| RBM7 | SF3B2 | ENSP00000439918 | ENSP00000318861 | RNA binding motif protein 7; Possible involved in germ cell RNA processing and meiosis | splicing factor 3b, subunit 2, 145kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron | 0.981 |
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