| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGAP17 | ARHGEF12 | ENSP00000289968 | ENSP00000380942 | Rho GTPase activating protein 17 | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.914 |
| ARHGAP17 | CDC42 | ENSP00000289968 | ENSP00000314458 | Rho GTPase activating protein 17 | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.976 |
| ARHGAP17 | MCF2L | ENSP00000289968 | ENSP00000440374 | Rho GTPase activating protein 17 | MCF.2 cell line derived transforming sequence-like | 0.941 |
| ARHGAP17 | RAC1 | ENSP00000289968 | ENSP00000348461 | Rho GTPase activating protein 17 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.972 |
| ARHGAP17 | RHOA | ENSP00000289968 | ENSP00000400175 | Rho GTPase activating protein 17 | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.934 |
| ARHGAP17 | RHOG | ENSP00000289968 | ENSP00000339467 | Rho GTPase activating protein 17 | ras homolog family member G; Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry | 0.908 |
| ARHGAP20 | ARHGEF12 | ENSP00000260283 | ENSP00000380942 | Rho GTPase activating protein 20 | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.917 |
| ARHGAP20 | CDC42 | ENSP00000260283 | ENSP00000314458 | Rho GTPase activating protein 20 | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.920 |
| ARHGAP20 | MCF2L | ENSP00000260283 | ENSP00000440374 | Rho GTPase activating protein 20 | MCF.2 cell line derived transforming sequence-like | 0.920 |
| ARHGAP20 | RHOA | ENSP00000260283 | ENSP00000400175 | Rho GTPase activating protein 20 | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.990 |
| ARHGAP20 | RHOG | ENSP00000260283 | ENSP00000339467 | Rho GTPase activating protein 20 | ras homolog family member G; Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry | 0.900 |
| ARHGAP25 | ARHGEF12 | ENSP00000386911 | ENSP00000380942 | Rho GTPase activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.914 |
| ARHGAP25 | CDC42 | ENSP00000386911 | ENSP00000314458 | Rho GTPase activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.925 |
| ARHGAP25 | MCF2L | ENSP00000386911 | ENSP00000440374 | Rho GTPase activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) | MCF.2 cell line derived transforming sequence-like | 0.931 |
| ARHGAP25 | RHOA | ENSP00000386911 | ENSP00000400175 | Rho GTPase activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.944 |
| ARHGAP25 | RHOG | ENSP00000386911 | ENSP00000339467 | Rho GTPase activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) | ras homolog family member G; Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry | 0.908 |
| ARHGAP44 | ARHGEF12 | ENSP00000368994 | ENSP00000380942 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.914 |
| ARHGAP44 | CDC42 | ENSP00000368994 | ENSP00000314458 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.962 |
| ARHGAP44 | MCF2L | ENSP00000368994 | ENSP00000440374 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | MCF.2 cell line derived transforming sequence-like | 0.941 |
| ARHGAP44 | RAC1 | ENSP00000368994 | ENSP00000348461 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.637 |
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