TIFAB protein (Homo sapiens) - STRING network view

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TIFAB

TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA (161 aa)

Predicted Functional Partners:

CTIF

0.773

TIFA

0.659

CATSPER3

0.567

TRAIP

0.505

DDX46

0.472

TRAF6

0.440

C5orf20

0.430

ANKRD45

0.407

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD45	TIFAB	ENSP00000331268	ENSP00000440509	ankyrin repeat domain 45	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	0.407
C5orf20	TIFAB	ENSP00000421871	ENSP00000440509	chromosome 5 open reading frame 20	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	0.430
CATSPER3	TIFAB	ENSP00000282611	ENSP00000440509	cation channel, sperm associated 3; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...]	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	0.567
CTIF	TIFAB	ENSP00000372459	ENSP00000440509	CBP80/20-dependent translation initiation factor; Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the p [...]	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	0.773
DDX46	TIFAB	ENSP00000346236	ENSP00000440509	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46; Plays an essential role in splicing, either prior to, or during splicing A complex formation	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	0.472
TIFA	TIFAB	ENSP00000354911	ENSP00000440509	TRAF-interacting protein with forkhead-associated domain; Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	0.659
TIFA	TRAF6	ENSP00000354911	ENSP00000337853	TRAF-interacting protein with forkhead-associated domain; Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism	TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...]	0.837
TIFAB	ANKRD45	ENSP00000440509	ENSP00000331268	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	ankyrin repeat domain 45	0.407
TIFAB	C5orf20	ENSP00000440509	ENSP00000421871	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	chromosome 5 open reading frame 20	0.430
TIFAB	CATSPER3	ENSP00000440509	ENSP00000282611	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	cation channel, sperm associated 3; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...]	0.567
TIFAB	CTIF	ENSP00000440509	ENSP00000372459	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	CBP80/20-dependent translation initiation factor; Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the p [...]	0.773
TIFAB	DDX46	ENSP00000440509	ENSP00000346236	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46; Plays an essential role in splicing, either prior to, or during splicing A complex formation	0.472
TIFAB	TIFA	ENSP00000440509	ENSP00000354911	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	TRAF-interacting protein with forkhead-associated domain; Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism	0.659
TIFAB	TRAF6	ENSP00000440509	ENSP00000337853	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...]	0.440
TIFAB	TRAIP	ENSP00000440509	ENSP00000328203	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	TRAF interacting protein; Inhibits activation of NF-kappa-B mediated by TNF (By similarity)	0.505
TRAF6	TIFA	ENSP00000337853	ENSP00000354911	TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...]	TRAF-interacting protein with forkhead-associated domain; Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism	0.837
TRAF6	TIFAB	ENSP00000337853	ENSP00000440509	TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...]	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	0.440
TRAF6	TRAIP	ENSP00000337853	ENSP00000328203	TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...]	TRAF interacting protein; Inhibits activation of NF-kappa-B mediated by TNF (By similarity)	0.753
TRAIP	TIFAB	ENSP00000328203	ENSP00000440509	TRAF interacting protein; Inhibits activation of NF-kappa-B mediated by TNF (By similarity)	TRAF-interacting protein with forkhead-associated domain, family member B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA	0.505
TRAIP	TRAF6	ENSP00000328203	ENSP00000337853	TRAF interacting protein; Inhibits activation of NF-kappa-B mediated by TNF (By similarity)	TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...]	0.753

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