node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT1 | DECR1 | ENSP00000270202 | ENSP00000220764 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | 2,4-dienoyl CoA reductase 1, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA | 0.961 |
AKT1 | NCF1 | ENSP00000270202 | ENSP00000289473 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | neutrophil cytosolic factor 1; May be required for activation of the latent NADPH oxidase (necessary for superoxide production) (By similarity) | 0.991 |
AKT1 | NCF2 | ENSP00000270202 | ENSP00000356505 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | neutrophil cytosolic factor 2 | 0.942 |
AKT1 | SYTL1 | ENSP00000270202 | ENSP00000440704 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | synaptotagmin-like 1; May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity) | 0.810 |
DECR1 | AKT1 | ENSP00000220764 | ENSP00000270202 | 2,4-dienoyl CoA reductase 1, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | 0.961 |
DECR1 | NCF1 | ENSP00000220764 | ENSP00000289473 | 2,4-dienoyl CoA reductase 1, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA | neutrophil cytosolic factor 1; May be required for activation of the latent NADPH oxidase (necessary for superoxide production) (By similarity) | 0.994 |
DECR1 | NCF2 | ENSP00000220764 | ENSP00000356505 | 2,4-dienoyl CoA reductase 1, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA | neutrophil cytosolic factor 2 | 0.979 |
DECR1 | SYTL1 | ENSP00000220764 | ENSP00000440704 | 2,4-dienoyl CoA reductase 1, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA | synaptotagmin-like 1; May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity) | 0.834 |
MYRIP | RAB27A | ENSP00000301972 | ENSP00000337761 | myosin VIIA and Rab interacting protein | RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse | 0.989 |
MYRIP | RAB27B | ENSP00000301972 | ENSP00000262094 | myosin VIIA and Rab interacting protein | RAB27B, member RAS oncogene family; May be involved in targeting uroplakins to urothelial apical membranes (By similarity) | 0.978 |
MYRIP | SYTL1 | ENSP00000301972 | ENSP00000440704 | myosin VIIA and Rab interacting protein | synaptotagmin-like 1; May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity) | 0.757 |
NCF1 | AKT1 | ENSP00000289473 | ENSP00000270202 | neutrophil cytosolic factor 1; May be required for activation of the latent NADPH oxidase (necessary for superoxide production) (By similarity) | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | 0.991 |
NCF1 | DECR1 | ENSP00000289473 | ENSP00000220764 | neutrophil cytosolic factor 1; May be required for activation of the latent NADPH oxidase (necessary for superoxide production) (By similarity) | 2,4-dienoyl CoA reductase 1, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA | 0.994 |
NCF1 | NCF2 | ENSP00000289473 | ENSP00000356505 | neutrophil cytosolic factor 1; May be required for activation of the latent NADPH oxidase (necessary for superoxide production) (By similarity) | neutrophil cytosolic factor 2 | 0.999 |
NCF1 | SYTL1 | ENSP00000289473 | ENSP00000440704 | neutrophil cytosolic factor 1; May be required for activation of the latent NADPH oxidase (necessary for superoxide production) (By similarity) | synaptotagmin-like 1; May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity) | 0.959 |
NCF2 | AKT1 | ENSP00000356505 | ENSP00000270202 | neutrophil cytosolic factor 2 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | 0.942 |
NCF2 | DECR1 | ENSP00000356505 | ENSP00000220764 | neutrophil cytosolic factor 2 | 2,4-dienoyl CoA reductase 1, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA | 0.979 |
NCF2 | NCF1 | ENSP00000356505 | ENSP00000289473 | neutrophil cytosolic factor 2 | neutrophil cytosolic factor 1; May be required for activation of the latent NADPH oxidase (necessary for superoxide production) (By similarity) | 0.999 |
NCF2 | SYTL1 | ENSP00000356505 | ENSP00000440704 | neutrophil cytosolic factor 2 | synaptotagmin-like 1; May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity) | 0.959 |
RAB27A | MYRIP | ENSP00000337761 | ENSP00000301972 | RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse | myosin VIIA and Rab interacting protein | 0.989 |