node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCKAR | PCDH7 | ENSP00000295589 | ENSP00000441802 | cholecystokinin A receptor; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system | protocadherin 7 | 0.749 |
CCKAR | STIM2 | ENSP00000295589 | ENSP00000417569 | cholecystokinin A receptor; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system | stromal interaction molecule 2; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRA [...] | 0.681 |
DDX28 | PCDH7 | ENSP00000332340 | ENSP00000441802 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 28; May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity | protocadherin 7 | 0.644 |
GTPBP1 | PCDH7 | ENSP00000216044 | ENSP00000441802 | GTP binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity) | protocadherin 7 | 0.810 |
GTPBP2 | PCDH7 | ENSP00000303997 | ENSP00000441802 | GTP binding protein 2 | protocadherin 7 | 0.814 |
HNRNPU | PCDH7 | ENSP00000283179 | ENSP00000441802 | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA | protocadherin 7 | 0.644 |
MARCKSL1 | PCDH7 | ENSP00000362638 | ENSP00000441802 | MARCKS-like 1; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity) | protocadherin 7 | 0.662 |
NT5E | PCDH7 | ENSP00000257770 | ENSP00000441802 | 5’-nucleotidase, ecto (CD73); Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities | protocadherin 7 | 0.644 |
PCDH7 | CCKAR | ENSP00000441802 | ENSP00000295589 | protocadherin 7 | cholecystokinin A receptor; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system | 0.749 |
PCDH7 | DDX28 | ENSP00000441802 | ENSP00000332340 | protocadherin 7 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 28; May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity | 0.644 |
PCDH7 | GTPBP1 | ENSP00000441802 | ENSP00000216044 | protocadherin 7 | GTP binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity) | 0.810 |
PCDH7 | GTPBP2 | ENSP00000441802 | ENSP00000303997 | protocadherin 7 | GTP binding protein 2 | 0.814 |
PCDH7 | HNRNPU | ENSP00000441802 | ENSP00000283179 | protocadherin 7 | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA | 0.644 |
PCDH7 | MARCKSL1 | ENSP00000441802 | ENSP00000362638 | protocadherin 7 | MARCKS-like 1; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity) | 0.662 |
PCDH7 | NT5E | ENSP00000441802 | ENSP00000257770 | protocadherin 7 | 5’-nucleotidase, ecto (CD73); Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities | 0.644 |
PCDH7 | STIM2 | ENSP00000441802 | ENSP00000417569 | protocadherin 7 | stromal interaction molecule 2; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRA [...] | 0.681 |
PCDH7 | TAF1 | ENSP00000441802 | ENSP00000276072 | protocadherin 7 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.750 |
PCDH7 | TAF1L | ENSP00000441802 | ENSP00000418379 | protocadherin 7 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced | 0.687 |
STIM2 | CCKAR | ENSP00000417569 | ENSP00000295589 | stromal interaction molecule 2; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRA [...] | cholecystokinin A receptor; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system | 0.681 |
STIM2 | PCDH7 | ENSP00000417569 | ENSP00000441802 | stromal interaction molecule 2; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRA [...] | protocadherin 7 | 0.681 |