node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C3orf37 | ENSG00000213121 | ENSP00000372955 | ENSP00000442163 | chromosome 3 open reading frame 37 | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | 0.495 |
ENSG00000213121 | C3orf37 | ENSP00000442163 | ENSP00000372955 | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | chromosome 3 open reading frame 37 | 0.495 |
ENSG00000213121 | HSP90AA1 | ENSP00000442163 | ENSP00000335153 | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.501 |
ENSG00000213121 | IPO7 | ENSP00000442163 | ENSP00000369042 | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | importin 7; Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm [...] | 0.495 |
ENSG00000213121 | NAP1L4 | ENSP00000442163 | ENSP00000369915 | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | nucleosome assembly protein 1-like 4 | 0.495 |
ENSG00000213121 | PABPC4 | ENSP00000442163 | ENSP00000361949 | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | poly(A) binding protein, cytoplasmic 4 (inducible form); Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity) | 0.495 |
ENSG00000213121 | PARP1 | ENSP00000442163 | ENSP00000355759 | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | poly (ADP-ribose) polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a [...] | 0.495 |
ENSG00000213121 | PCNA | ENSP00000442163 | ENSP00000368438 | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] | 0.495 |
ENSG00000213121 | PURB | ENSP00000442163 | ENSP00000379051 | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | purine-rich element binding protein B; Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May pla [...] | 0.508 |
ENSG00000213121 | TMEM19 | ENSP00000442163 | ENSP00000266673 | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | transmembrane protein 19 | 0.501 |
ENSG00000213121 | ZCCHC3 | ENSP00000442163 | ENSP00000371789 | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | zinc finger, CCHC domain containing 3 | 0.495 |
HSP90AA1 | ENSG00000213121 | ENSP00000335153 | ENSP00000442163 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | 0.501 |
HSP90AA1 | PARP1 | ENSP00000335153 | ENSP00000355759 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | poly (ADP-ribose) polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a [...] | 0.416 |
HSP90AA1 | PCNA | ENSP00000335153 | ENSP00000368438 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] | 0.571 |
IPO7 | ENSG00000213121 | ENSP00000369042 | ENSP00000442163 | importin 7; Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm [...] | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | 0.495 |
NAP1L4 | ENSG00000213121 | ENSP00000369915 | ENSP00000442163 | nucleosome assembly protein 1-like 4 | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | 0.495 |
PABPC4 | ENSG00000213121 | ENSP00000361949 | ENSP00000442163 | poly(A) binding protein, cytoplasmic 4 (inducible form); Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity) | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | 0.495 |
PARP1 | ENSG00000213121 | ENSP00000355759 | ENSP00000442163 | poly (ADP-ribose) polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a [...] | Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog | 0.495 |
PARP1 | HSP90AA1 | ENSP00000355759 | ENSP00000335153 | poly (ADP-ribose) polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a [...] | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.416 |
PARP1 | PCNA | ENSP00000355759 | ENSP00000368438 | poly (ADP-ribose) polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a [...] | proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] | 0.990 |