| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| A1CF | ASIC5 | ENSP00000282641 | ENSP00000442477 | APOBEC1 complementation factor | acid-sensing (proton-gated) ion channel family member 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride | 0.598 |
| A1CF | GDI1 | ENSP00000282641 | ENSP00000394071 | APOBEC1 complementation factor | GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | 0.508 |
| A1CF | GDI2 | ENSP00000282641 | ENSP00000369538 | APOBEC1 complementation factor | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | 0.508 |
| ASIC5 | A1CF | ENSP00000442477 | ENSP00000282641 | acid-sensing (proton-gated) ion channel family member 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride | APOBEC1 complementation factor | 0.598 |
| ASIC5 | EXO5 | ENSP00000442477 | ENSP00000296380 | acid-sensing (proton-gated) ion channel family member 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride | exonuclease 5; Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5’-3’ and 3’-5’ exonuclease activities with a strong preference for 5’-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3’-5’ exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5’-directionality activity | 0.592 |
| ASIC5 | FTH1 | ENSP00000442477 | ENSP00000273550 | acid-sensing (proton-gated) ion channel family member 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | 0.424 |
| ASIC5 | GDI1 | ENSP00000442477 | ENSP00000394071 | acid-sensing (proton-gated) ion channel family member 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride | GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | 0.517 |
| ASIC5 | GDI2 | ENSP00000442477 | ENSP00000369538 | acid-sensing (proton-gated) ion channel family member 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | 0.518 |
| ASIC5 | RBM47 | ENSP00000442477 | ENSP00000295971 | acid-sensing (proton-gated) ion channel family member 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride | RNA binding motif protein 47 | 0.483 |
| ASIC5 | SGCG | ENSP00000442477 | ENSP00000218867 | acid-sensing (proton-gated) ion channel family member 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein); Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix | 0.405 |
| EXO5 | ASIC5 | ENSP00000296380 | ENSP00000442477 | exonuclease 5; Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5’-3’ and 3’-5’ exonuclease activities with a strong preference for 5’-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3’-5’ exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5’-directionality activity | acid-sensing (proton-gated) ion channel family member 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride | 0.592 |
| FTH1 | ASIC5 | ENSP00000273550 | ENSP00000442477 | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | acid-sensing (proton-gated) ion channel family member 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride | 0.424 |
| FTH1 | SGCG | ENSP00000273550 | ENSP00000218867 | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein); Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix | 0.582 |
| GDI1 | A1CF | ENSP00000394071 | ENSP00000282641 | GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | APOBEC1 complementation factor | 0.508 |
| GDI1 | ASIC5 | ENSP00000394071 | ENSP00000442477 | GDP dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | acid-sensing (proton-gated) ion channel family member 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride | 0.517 |
| GDI2 | A1CF | ENSP00000369538 | ENSP00000282641 | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | APOBEC1 complementation factor | 0.508 |
| GDI2 | ASIC5 | ENSP00000369538 | ENSP00000442477 | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | acid-sensing (proton-gated) ion channel family member 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride | 0.518 |
| GDI2 | RBM47 | ENSP00000369538 | ENSP00000295971 | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | RNA binding motif protein 47 | 0.417 |
| RBM47 | ASIC5 | ENSP00000295971 | ENSP00000442477 | RNA binding motif protein 47 | acid-sensing (proton-gated) ion channel family member 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride | 0.483 |
| RBM47 | GDI2 | ENSP00000295971 | ENSP00000369538 | RNA binding motif protein 47 | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them | 0.417 |
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