node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CREB3L1 | MFSD5 | ENSP00000434939 | ENSP00000442688 | cAMP responsive element binding protein 3-like 1; Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity) | major facilitator superfamily domain containing 5 | 0.543 |
GDPD5 | ITGAD | ENSP00000337972 | ENSP00000373854 | glycerophosphodiester phosphodiesterase domain containing 5; Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine | integrin, alpha D; Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood- borne pathogens, particulate matter, and senescent erythrocytes from the blood | 0.410 |
GDPD5 | MFSD5 | ENSP00000337972 | ENSP00000442688 | glycerophosphodiester phosphodiesterase domain containing 5; Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine | major facilitator superfamily domain containing 5 | 0.591 |
ITGAD | GDPD5 | ENSP00000373854 | ENSP00000337972 | integrin, alpha D; Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood- borne pathogens, particulate matter, and senescent erythrocytes from the blood | glycerophosphodiester phosphodiesterase domain containing 5; Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine | 0.410 |
ITGAD | MFSD5 | ENSP00000373854 | ENSP00000442688 | integrin, alpha D; Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood- borne pathogens, particulate matter, and senescent erythrocytes from the blood | major facilitator superfamily domain containing 5 | 0.536 |
KDM6B | MFSD5 | ENSP00000254846 | ENSP00000442688 | lysine (K)-specific demethylase 6B; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation | major facilitator superfamily domain containing 5 | 0.485 |
MFSD5 | CREB3L1 | ENSP00000442688 | ENSP00000434939 | major facilitator superfamily domain containing 5 | cAMP responsive element binding protein 3-like 1; Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity) | 0.543 |
MFSD5 | GDPD5 | ENSP00000442688 | ENSP00000337972 | major facilitator superfamily domain containing 5 | glycerophosphodiester phosphodiesterase domain containing 5; Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine | 0.591 |
MFSD5 | ITGAD | ENSP00000442688 | ENSP00000373854 | major facilitator superfamily domain containing 5 | integrin, alpha D; Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood- borne pathogens, particulate matter, and senescent erythrocytes from the blood | 0.536 |
MFSD5 | KDM6B | ENSP00000442688 | ENSP00000254846 | major facilitator superfamily domain containing 5 | lysine (K)-specific demethylase 6B; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation | 0.485 |
MFSD5 | SAMD4A | ENSP00000442688 | ENSP00000350261 | major facilitator superfamily domain containing 5 | sterile alpha motif domain containing 4A; Acts as a translational repressor of SRE-containing messengers | 0.485 |
MFSD5 | SAMD4B | ENSP00000442688 | ENSP00000317224 | major facilitator superfamily domain containing 5 | sterile alpha motif domain containing 4B; Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A | 0.592 |
MFSD5 | SLC15A5 | ENSP00000442688 | ENSP00000340402 | major facilitator superfamily domain containing 5 | solute carrier family 15, member 5; Proton oligopeptide cotransporter (Potential) | 0.723 |
MFSD5 | SLC7A14 | ENSP00000442688 | ENSP00000231706 | major facilitator superfamily domain containing 5 | solute carrier family 7 (orphan transporter), member 14 | 0.501 |
MFSD5 | SLCO1B7 | ENSP00000442688 | ENSP00000394168 | major facilitator superfamily domain containing 5 | solute carrier organic anion transporter family, member 1B7 (non-functional) | 0.583 |
MFSD5 | SMGA | ENSP00000442688 | ENSP00000306381 | major facilitator superfamily domain containing 5 | Protein Smaug homolog 1 | 0.485 |
SAMD4A | MFSD5 | ENSP00000350261 | ENSP00000442688 | sterile alpha motif domain containing 4A; Acts as a translational repressor of SRE-containing messengers | major facilitator superfamily domain containing 5 | 0.485 |
SAMD4B | MFSD5 | ENSP00000317224 | ENSP00000442688 | sterile alpha motif domain containing 4B; Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A | major facilitator superfamily domain containing 5 | 0.592 |
SLC15A5 | MFSD5 | ENSP00000340402 | ENSP00000442688 | solute carrier family 15, member 5; Proton oligopeptide cotransporter (Potential) | major facilitator superfamily domain containing 5 | 0.723 |
SLC15A5 | SLC7A14 | ENSP00000340402 | ENSP00000231706 | solute carrier family 15, member 5; Proton oligopeptide cotransporter (Potential) | solute carrier family 7 (orphan transporter), member 14 | 0.704 |