| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCD2 | ABCD3 | ENSP00000310688 | ENSP00000359233 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | 0.622 |
| ABCD2 | ACSBG1 | ENSP00000310688 | ENSP00000258873 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids | 0.906 |
| ABCD2 | BCAP31 | ENSP00000310688 | ENSP00000392330 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | B-cell receptor-associated protein 31; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis | 0.749 |
| ABCD2 | PLXNB3 | ENSP00000310688 | ENSP00000442736 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | plexin B3; Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1 | 0.749 |
| ABCD2 | SLC27A2 | ENSP00000310688 | ENSP00000267842 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | solute carrier family 27 (fatty acid transporter), member 2; Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fat [...] | 0.775 |
| ABCD3 | ABCD2 | ENSP00000359233 | ENSP00000310688 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | 0.622 |
| ABCD3 | ACSBG1 | ENSP00000359233 | ENSP00000258873 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids | 0.883 |
| ABCD3 | BCAP31 | ENSP00000359233 | ENSP00000392330 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | B-cell receptor-associated protein 31; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis | 0.723 |
| ABCD3 | PLXNB3 | ENSP00000359233 | ENSP00000442736 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | plexin B3; Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1 | 0.723 |
| ABCD3 | SLC27A2 | ENSP00000359233 | ENSP00000267842 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | solute carrier family 27 (fatty acid transporter), member 2; Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fat [...] | 0.768 |
| ABCD4 | ACSBG1 | ENSP00000349396 | ENSP00000258873 | ATP-binding cassette, sub-family D (ALD), member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm | acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids | 0.822 |
| ABCD4 | BCAP31 | ENSP00000349396 | ENSP00000392330 | ATP-binding cassette, sub-family D (ALD), member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm | B-cell receptor-associated protein 31; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis | 0.680 |
| ABCD4 | PLXNB3 | ENSP00000349396 | ENSP00000442736 | ATP-binding cassette, sub-family D (ALD), member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm | plexin B3; Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1 | 0.680 |
| ABCD4 | SLC27A2 | ENSP00000349396 | ENSP00000267842 | ATP-binding cassette, sub-family D (ALD), member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm | solute carrier family 27 (fatty acid transporter), member 2; Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fat [...] | 0.697 |
| ACSBG1 | ABCD2 | ENSP00000258873 | ENSP00000310688 | acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | 0.906 |
| ACSBG1 | ABCD3 | ENSP00000258873 | ENSP00000359233 | acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | 0.883 |
| ACSBG1 | ABCD4 | ENSP00000258873 | ENSP00000349396 | acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids | ATP-binding cassette, sub-family D (ALD), member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm | 0.822 |
| ACSBG1 | BCAP31 | ENSP00000258873 | ENSP00000392330 | acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids | B-cell receptor-associated protein 31; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis | 0.757 |
| ACSBG1 | PLXNB3 | ENSP00000258873 | ENSP00000442736 | acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids | plexin B3; Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1 | 0.748 |
| ACSBG1 | SLC27A2 | ENSP00000258873 | ENSP00000267842 | acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids | solute carrier family 27 (fatty acid transporter), member 2; Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fat [...] | 0.896 |
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