node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATXN10 | ATXN7 | ENSP00000252934 | ENSP00000381590 | ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity) | ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization | 0.756 |
ATXN10 | BEAN1 | ENSP00000252934 | ENSP00000442793 | ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity) | brain expressed, associated with NEDD4, 1 | 0.584 |
ATXN10 | CACNA1A | ENSP00000252934 | ENSP00000353362 | ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity) | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 0.647 |
ATXN10 | PDYN | ENSP00000252934 | ENSP00000217305 | ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity) | prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) | 0.608 |
ATXN10 | PLEKHG4 | ENSP00000252934 | ENSP00000353646 | ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity) | pleckstrin homology domain containing, family G (with RhoGef domain) member 4; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi | 0.751 |
ATXN10 | PPP2R2B | ENSP00000252934 | ENSP00000336591 | ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity) | protein phosphatase 2, regulatory subunit B, beta | 0.820 |
ATXN10 | SPTBN2 | ENSP00000252934 | ENSP00000311489 | ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity) | spectrin, beta, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton | 0.741 |
ATXN10 | TTBK2 | ENSP00000252934 | ENSP00000267890 | ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity) | tau tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis- controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro | 0.564 |
ATXN7 | ATXN10 | ENSP00000381590 | ENSP00000252934 | ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization | ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity) | 0.756 |
ATXN7 | BEAN1 | ENSP00000381590 | ENSP00000442793 | ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization | brain expressed, associated with NEDD4, 1 | 0.471 |
ATXN7 | CACNA1A | ENSP00000381590 | ENSP00000353362 | ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 0.817 |
ATXN7 | PDYN | ENSP00000381590 | ENSP00000217305 | ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization | prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) | 0.659 |
ATXN7 | PLEKHG4 | ENSP00000381590 | ENSP00000353646 | ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization | pleckstrin homology domain containing, family G (with RhoGef domain) member 4; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi | 0.722 |
ATXN7 | PPP2R2B | ENSP00000381590 | ENSP00000336591 | ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization | protein phosphatase 2, regulatory subunit B, beta | 0.811 |
ATXN7 | SPTBN2 | ENSP00000381590 | ENSP00000311489 | ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization | spectrin, beta, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton | 0.650 |
ATXN7 | TTBK2 | ENSP00000381590 | ENSP00000267890 | ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization | tau tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis- controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro | 0.459 |
BEAN1 | ATXN10 | ENSP00000442793 | ENSP00000252934 | brain expressed, associated with NEDD4, 1 | ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity) | 0.584 |
BEAN1 | ATXN7 | ENSP00000442793 | ENSP00000381590 | brain expressed, associated with NEDD4, 1 | ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization | 0.471 |
BEAN1 | CACNA1A | ENSP00000442793 | ENSP00000353362 | brain expressed, associated with NEDD4, 1 | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 0.472 |
BEAN1 | CALB1 | ENSP00000442793 | ENSP00000265431 | brain expressed, associated with NEDD4, 1 | calbindin 1, 28kDa; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase | 0.603 |