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STRINGSTRING
SRSF9 SRSF9 CALB1 CALB1 BEAN1 BEAN1 ATXN7 ATXN7 PLEKHG4 PLEKHG4 PDYN PDYN CACNA1A CACNA1A SPTBN2 SPTBN2 ATXN10 ATXN10 PPP2R2B PPP2R2B TTBK2 TTBK2
"BEAN1" - brain expressed, associated with NEDD4, 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
BEAN1brain expressed, associated with NEDD4, 1 (259 aa)    
Predicted Functional Partners:
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi (1191 aa)
            score_image   0.759
TTBK2
tau tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis- controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (1244 aa)
            score_image   0.660
PDYN
prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) (254 aa)
            score_image   0.609
CALB1
calbindin 1, 28kDa; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase (261 aa)
            score_image   0.603
SPTBN2
spectrin, beta, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton (2390 aa)
            score_image   0.584
ATXN10
ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity) (475 aa)
            score_image   0.584
SRSF9
serine/arginine-rich splicing factor 9; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 (221 aa)
            score_image   0.518
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta (446 aa)
            score_image   0.499
CACNA1A
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (2506 aa)
            score_image   0.472
ATXN7
ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization (945 aa)
            score_image   0.471
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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