SHD protein (Homo sapiens) - STRING network view

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Score

SHD

Src homology 2 domain containing transforming protein D; May function as an adapter protein (By similarity) (340 aa)

Predicted Functional Partners:

ABL1

0.715

EFTUD1

0.574

TRIP4

0.573

MKS1

0.485

MPV17

0.453

SPIC

0.452

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	SHD	ENSP00000361423	ENSP00000446058	c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...]	Src homology 2 domain containing transforming protein D; May function as an adapter protein (By similarity)	0.715
EFTUD1	SHD	ENSP00000268206	ENSP00000446058	elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits	Src homology 2 domain containing transforming protein D; May function as an adapter protein (By similarity)	0.574
MKS1	SHD	ENSP00000376827	ENSP00000446058	Meckel syndrome, type 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology	Src homology 2 domain containing transforming protein D; May function as an adapter protein (By similarity)	0.485
MPV17	SHD	ENSP00000233545	ENSP00000446058	MpV17 mitochondrial inner membrane protein; Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance	Src homology 2 domain containing transforming protein D; May function as an adapter protein (By similarity)	0.453
SHD	ABL1	ENSP00000446058	ENSP00000361423	Src homology 2 domain containing transforming protein D; May function as an adapter protein (By similarity)	c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...]	0.715
SHD	EFTUD1	ENSP00000446058	ENSP00000268206	Src homology 2 domain containing transforming protein D; May function as an adapter protein (By similarity)	elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits	0.574
SHD	MKS1	ENSP00000446058	ENSP00000376827	Src homology 2 domain containing transforming protein D; May function as an adapter protein (By similarity)	Meckel syndrome, type 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology	0.485
SHD	MPV17	ENSP00000446058	ENSP00000233545	Src homology 2 domain containing transforming protein D; May function as an adapter protein (By similarity)	MpV17 mitochondrial inner membrane protein; Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance	0.453
SHD	SPIC	ENSP00000446058	ENSP00000299272	Src homology 2 domain containing transforming protein D; May function as an adapter protein (By similarity)	Spi-C transcription factor (Spi-1/PU.1 related); Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5’-GAGGA[AT]-3’) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity)	0.452
SHD	TRIP4	ENSP00000446058	ENSP00000261884	Src homology 2 domain containing transforming protein D; May function as an adapter protein (By similarity)	thyroid hormone receptor interactor 4; Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF- kappa-B. Plays a role in androgen receptor transactivation and in testicular function (By similarity)	0.573
SPIC	SHD	ENSP00000299272	ENSP00000446058	Spi-C transcription factor (Spi-1/PU.1 related); Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5’-GAGGA[AT]-3’) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity)	Src homology 2 domain containing transforming protein D; May function as an adapter protein (By similarity)	0.452
TRIP4	SHD	ENSP00000261884	ENSP00000446058	thyroid hormone receptor interactor 4; Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF- kappa-B. Plays a role in androgen receptor transactivation and in testicular function (By similarity)	Src homology 2 domain containing transforming protein D; May function as an adapter protein (By similarity)	0.573

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