NAV3 protein (Homo sapiens) - STRING network view

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NAV3

neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration (2363 aa)

Predicted Functional Partners:

GRB2

0.732

GRAP

0.727

LHX3

0.701

LHX4

0.701

GRAPL

0.674

GRAP2

0.674

CNN1

0.667

TRIO

0.610

MAPRE1

0.570

NCKIPSD

0.531

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNN1	MAPRE1	ENSP00000252456	ENSP00000364721	calponin 1, basic, smooth muscle; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)	microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration	0.493
CNN1	NAV3	ENSP00000252456	ENSP00000446132	calponin 1, basic, smooth muscle; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	0.667
GRAP	GRAP2	ENSP00000284154	ENSP00000339186	GRB2-related adaptor protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway	GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc	0.906
GRAP	NAV3	ENSP00000284154	ENSP00000446132	GRB2-related adaptor protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	0.727
GRAP2	GRAP	ENSP00000339186	ENSP00000284154	GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc	GRB2-related adaptor protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway	0.906
GRAP2	NAV3	ENSP00000339186	ENSP00000446132	GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	0.674
GRAPL	NAV3	ENSP00000437409	ENSP00000446132	GRB2-related adaptor protein-like	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	0.674
GRB2	NAV3	ENSP00000339007	ENSP00000446132	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	0.732
GRB2	NCKIPSD	ENSP00000339007	ENSP00000294129	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway	NCK interacting protein with SH3 domain; Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP- induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis	0.885
LHX3	NAV3	ENSP00000360811	ENSP00000446132	LIM homeobox 3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	0.701
LHX4	NAV3	ENSP00000263726	ENSP00000446132	LIM homeobox 4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung (By similarity)	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	0.701
MAPRE1	CNN1	ENSP00000364721	ENSP00000252456	microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration	calponin 1, basic, smooth muscle; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)	0.493
MAPRE1	NAV3	ENSP00000364721	ENSP00000446132	microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	0.570
MAPRE1	TRIO	ENSP00000364721	ENSP00000339299	microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration	trio Rho guanine nucleotide exchange factor; Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth	0.570
NAV3	CNN1	ENSP00000446132	ENSP00000252456	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	calponin 1, basic, smooth muscle; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)	0.667
NAV3	GRAP	ENSP00000446132	ENSP00000284154	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	GRB2-related adaptor protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway	0.727
NAV3	GRAP2	ENSP00000446132	ENSP00000339186	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc	0.674
NAV3	GRAPL	ENSP00000446132	ENSP00000437409	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	GRB2-related adaptor protein-like	0.674
NAV3	GRB2	ENSP00000446132	ENSP00000339007	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway	0.732
NAV3	LHX3	ENSP00000446132	ENSP00000360811	neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration	LIM homeobox 3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1	0.701

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