| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCB11 | CYP7A1 | ENSP00000263817 | ENSP00000301645 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | 0.824 |
| ABCB11 | FABP6 | ENSP00000263817 | ENSP00000377549 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | 0.757 |
| ABCB11 | INS | ENSP00000263817 | ENSP00000250971 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.412 |
| ABCB11 | NISCH | ENSP00000263817 | ENSP00000339958 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | nischarin | 0.540 |
| ABCB11 | NR0B2 | ENSP00000263817 | ENSP00000254227 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | nuclear receptor subfamily 0, group B, member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1 | 0.664 |
| ABCB11 | NR1H4 | ENSP00000263817 | ENSP00000447149 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | nuclear receptor subfamily 1, group H, member 4; Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus | 0.962 |
| CYP7A1 | ABCB11 | ENSP00000301645 | ENSP00000263817 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | 0.824 |
| CYP7A1 | FABP6 | ENSP00000301645 | ENSP00000377549 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | 0.721 |
| CYP7A1 | GPS2 | ENSP00000301645 | ENSP00000370104 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | G protein pathway suppressor 2; Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction | 0.898 |
| CYP7A1 | INS | ENSP00000301645 | ENSP00000250971 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.896 |
| CYP7A1 | MED1 | ENSP00000301645 | ENSP00000300651 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | 0.922 |
| CYP7A1 | NISCH | ENSP00000301645 | ENSP00000339958 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | nischarin | 0.499 |
| CYP7A1 | NR0B2 | ENSP00000301645 | ENSP00000254227 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | nuclear receptor subfamily 0, group B, member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1 | 0.955 |
| CYP7A1 | NR1H4 | ENSP00000301645 | ENSP00000447149 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | nuclear receptor subfamily 1, group H, member 4; Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus | 0.966 |
| CYP7A1 | RXRG | ENSP00000301645 | ENSP00000352900 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | retinoid X receptor, gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity) | 0.470 |
| EIF2C2 | NR1H4 | ENSP00000220592 | ENSP00000447149 | eukaryotic translation initiation factor 2C, 2; Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The ’minimal RISC’ appears to include EIF2C2/AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC- mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due [...] | nuclear receptor subfamily 1, group H, member 4; Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus | 0.880 |
| FABP6 | ABCB11 | ENSP00000377549 | ENSP00000263817 | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | 0.757 |
| FABP6 | CYP7A1 | ENSP00000377549 | ENSP00000301645 | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | 0.721 |
| FABP6 | MED1 | ENSP00000377549 | ENSP00000300651 | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | 0.410 |
| FABP6 | NISCH | ENSP00000377549 | ENSP00000339958 | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | nischarin | 0.623 |
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