FKBP11 protein (Homo sapiens) - STRING network view

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FKBP11

FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis (201 aa)

Predicted Functional Partners:

IFITM5

0.864

PAX4

0.745

NKX2-5

0.651

PDIA4

0.574

PPIC

0.571

FKBP6

0.535

TXNDC11

0.534

PDIA3

0.499

SUMF2

0.491

P4HB

0.486

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FKBP11	FKBP6	ENSP00000449751	ENSP00000252037	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	FK506 binding protein 6, 36kDa	0.535
FKBP11	IFITM5	ENSP00000449751	ENSP00000372059	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	interferon induced transmembrane protein 5; Plays a role in bone mineralization (By similarity)	0.864
FKBP11	NKX2-5	ENSP00000449751	ENSP00000327758	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	NK2 homeobox 5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity)	0.651
FKBP11	P4HB	ENSP00000449751	ENSP00000327801	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	prolyl 4-hydroxylase, beta polypeptide; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with [...]	0.486
FKBP11	PAX4	ENSP00000449751	ENSP00000339906	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	paired box 4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity	0.745
FKBP11	PDIA3	ENSP00000449751	ENSP00000300289	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	protein disulfide isomerase family A, member 3	0.499
FKBP11	PDIA4	ENSP00000449751	ENSP00000286091	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	protein disulfide isomerase family A, member 4	0.574
FKBP11	PPIC	ENSP00000449751	ENSP00000303057	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	peptidylprolyl isomerase C (cyclophilin C); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)	0.571
FKBP11	SUMF2	ENSP00000449751	ENSP00000341938	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	sulfatase modifying factor 2	0.491
FKBP11	TXNDC11	ENSP00000449751	ENSP00000283033	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	thioredoxin domain containing 11; May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation	0.534
FKBP6	FKBP11	ENSP00000252037	ENSP00000449751	FK506 binding protein 6, 36kDa	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	0.535
IFITM5	FKBP11	ENSP00000372059	ENSP00000449751	interferon induced transmembrane protein 5; Plays a role in bone mineralization (By similarity)	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	0.864
NKX2-5	FKBP11	ENSP00000327758	ENSP00000449751	NK2 homeobox 5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity)	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	0.651
P4HB	FKBP11	ENSP00000327801	ENSP00000449751	prolyl 4-hydroxylase, beta polypeptide; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with [...]	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	0.486
P4HB	PDIA3	ENSP00000327801	ENSP00000300289	prolyl 4-hydroxylase, beta polypeptide; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with [...]	protein disulfide isomerase family A, member 3	0.822
P4HB	PDIA4	ENSP00000327801	ENSP00000286091	prolyl 4-hydroxylase, beta polypeptide; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with [...]	protein disulfide isomerase family A, member 4	0.826
P4HB	PPIC	ENSP00000327801	ENSP00000303057	prolyl 4-hydroxylase, beta polypeptide; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with [...]	peptidylprolyl isomerase C (cyclophilin C); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)	0.613
PAX4	FKBP11	ENSP00000339906	ENSP00000449751	paired box 4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	0.745
PDIA3	FKBP11	ENSP00000300289	ENSP00000449751	protein disulfide isomerase family A, member 3	FK506 binding protein 11, 19 kDa; PPIases accelerate the folding of proteins during protein synthesis	0.499
PDIA3	P4HB	ENSP00000300289	ENSP00000327801	protein disulfide isomerase family A, member 3	prolyl 4-hydroxylase, beta polypeptide; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with [...]	0.822

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