ENSG00000257411 protein (Homo sapiens)

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protein of unknown 3D structure

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Score

ENSG00000257411

Uncharacterized protein (163 aa)

Predicted Functional Partners:

NMD3

0.987

GTPBP4

0.985

MRTO4

0.984

RRP12

0.978

GNL3

0.977

GNL3L

0.977

RPF2

0.975

NIP7

0.975

PES1

0.975

RSL24D1

0.974

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSG00000257411	GNL3	ENSP00000449770	ENSP00000395772	Uncharacterized protein	guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)	0.977
ENSG00000257411	GNL3L	ENSP00000449770	ENSP00000338573	Uncharacterized protein	guanine nucleotide binding protein-like 3 (nucleolar)-like; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal pr [...]	0.977
ENSG00000257411	GTPBP4	ENSP00000449770	ENSP00000354040	Uncharacterized protein	GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity)	0.985
ENSG00000257411	MRTO4	ENSP00000449770	ENSP00000364320	Uncharacterized protein	mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity)	0.984
ENSG00000257411	NIP7	ENSP00000449770	ENSP00000254940	Uncharacterized protein	nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly	0.975
ENSG00000257411	NMD3	ENSP00000449770	ENSP00000307525	Uncharacterized protein	NMD3 homolog (S. cerevisiae); Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit	0.987
ENSG00000257411	PES1	ENSP00000449770	ENSP00000346725	Uncharacterized protein	pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.975
ENSG00000257411	RPF2	ENSP00000449770	ENSP00000402338	Uncharacterized protein	ribosome production factor 2 homolog (S. cerevisiae)	0.975
ENSG00000257411	RRP12	ENSP00000449770	ENSP00000360031	Uncharacterized protein	ribosomal RNA processing 12 homolog (S. cerevisiae)	0.978
ENSG00000257411	RSL24D1	ENSP00000449770	ENSP00000260443	Uncharacterized protein	ribosomal L24 domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity)	0.974
GNL3	ENSG00000257411	ENSP00000395772	ENSP00000449770	guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)	Uncharacterized protein	0.977
GNL3	GTPBP4	ENSP00000395772	ENSP00000354040	guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)	GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity)	0.992
GNL3	MRTO4	ENSP00000395772	ENSP00000364320	guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)	mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity)	0.988
GNL3	NIP7	ENSP00000395772	ENSP00000254940	guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)	nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly	0.979
GNL3	NMD3	ENSP00000395772	ENSP00000307525	guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)	NMD3 homolog (S. cerevisiae); Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit	0.950
GNL3	PES1	ENSP00000395772	ENSP00000346725	guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)	pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.996
GNL3	RPF2	ENSP00000395772	ENSP00000402338	guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)	ribosome production factor 2 homolog (S. cerevisiae)	0.986
GNL3	RRP12	ENSP00000395772	ENSP00000360031	guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)	ribosomal RNA processing 12 homolog (S. cerevisiae)	0.895
GNL3	RSL24D1	ENSP00000395772	ENSP00000260443	guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)	ribosomal L24 domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity)	0.881
GNL3L	ENSG00000257411	ENSP00000338573	ENSP00000449770	guanine nucleotide binding protein-like 3 (nucleolar)-like; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal pr [...]	Uncharacterized protein	0.977

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