node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | ASPG | ENSP00000253792 | ENSP00000450040 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | asparaginase homolog (S. cerevisiae); Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities | 0.639 |
ACLY | CAD | ENSP00000253792 | ENSP00000264705 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.867 |
ACLY | CAT | ENSP00000253792 | ENSP00000241052 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells | 0.716 |
ACLY | GART | ENSP00000253792 | ENSP00000371236 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | 0.788 |
ASGR1 | ASPG | ENSP00000269299 | ENSP00000450040 | asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface | asparaginase homolog (S. cerevisiae); Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities | 0.580 |
ASPG | ACLY | ENSP00000450040 | ENSP00000253792 | asparaginase homolog (S. cerevisiae); Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.639 |
ASPG | ASGR1 | ENSP00000450040 | ENSP00000269299 | asparaginase homolog (S. cerevisiae); Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities | asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface | 0.580 |
ASPG | CAD | ENSP00000450040 | ENSP00000264705 | asparaginase homolog (S. cerevisiae); Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.581 |
ASPG | CAT | ENSP00000450040 | ENSP00000241052 | asparaginase homolog (S. cerevisiae); Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities | catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells | 0.617 |
ASPG | CHRNE | ENSP00000450040 | ENSP00000293780 | asparaginase homolog (S. cerevisiae); Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities | cholinergic receptor, nicotinic, epsilon (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.744 |
ASPG | CNR2 | ENSP00000450040 | ENSP00000363596 | asparaginase homolog (S. cerevisiae); Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities | cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis | 0.610 |
ASPG | GART | ENSP00000450040 | ENSP00000371236 | asparaginase homolog (S. cerevisiae); Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | 0.638 |
ASPG | GP1BA | ENSP00000450040 | ENSP00000329380 | asparaginase homolog (S. cerevisiae); Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities | glycoprotein Ib (platelet), alpha polypeptide; GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium | 0.720 |
ASPG | LRGUK | ENSP00000450040 | ENSP00000285928 | asparaginase homolog (S. cerevisiae); Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities | leucine-rich repeats and guanylate kinase domain containing | 0.567 |
ASPG | SUCNR1 | ENSP00000450040 | ENSP00000355156 | asparaginase homolog (S. cerevisiae); Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities | succinate receptor 1; Receptor for succinate | 0.590 |
CAD | ACLY | ENSP00000264705 | ENSP00000253792 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.867 |
CAD | ASPG | ENSP00000264705 | ENSP00000450040 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | asparaginase homolog (S. cerevisiae); Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities | 0.581 |
CAD | GART | ENSP00000264705 | ENSP00000371236 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | 0.967 |
CAD | LRGUK | ENSP00000264705 | ENSP00000285928 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | leucine-rich repeats and guanylate kinase domain containing | 0.853 |
CAT | ACLY | ENSP00000241052 | ENSP00000253792 | catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.716 |