CHURC1 protein (Homo sapiens) - STRING network view

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CHURC1

churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself (140 aa)

Predicted Functional Partners:

PLAG1

0.759

CHCHD7

0.746

ZSWIM7

0.735

ZEB2

0.683

C10orf85

0.635

PCDH17

0.620

RNF43

0.525

NPAS4

0.523

SETMAR

0.512

COX19

0.504

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C10orf85	CHURC1	ENSP00000358067	ENSP00000450144	chromosome 10 open reading frame 85	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	0.635
CHCHD7	CHURC1	ENSP00000306425	ENSP00000450144	coiled-coil-helix-coiled-coil-helix domain containing 7	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	0.746
CHCHD7	COX19	ENSP00000306425	ENSP00000342015	coiled-coil-helix-coiled-coil-helix domain containing 7	cytochrome c oxidase assembly homolog 19 (S. cerevisiae); May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity)	0.873
CHCHD7	PLAG1	ENSP00000306425	ENSP00000325546	coiled-coil-helix-coiled-coil-helix domain containing 7	pleiomorphic adenoma gene 1; Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation- when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hep [...]	0.782
CHURC1	C10orf85	ENSP00000450144	ENSP00000358067	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	chromosome 10 open reading frame 85	0.635
CHURC1	CHCHD7	ENSP00000450144	ENSP00000306425	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	coiled-coil-helix-coiled-coil-helix domain containing 7	0.746
CHURC1	COX19	ENSP00000450144	ENSP00000342015	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	cytochrome c oxidase assembly homolog 19 (S. cerevisiae); May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity)	0.504
CHURC1	NPAS4	ENSP00000450144	ENSP00000311196	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	neuronal PAS domain protein 4; Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene	0.523
CHURC1	PCDH17	ENSP00000450144	ENSP00000367151	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	protocadherin 17; Potential calcium-dependent cell-adhesion protein	0.620
CHURC1	PLAG1	ENSP00000450144	ENSP00000325546	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	pleiomorphic adenoma gene 1; Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation- when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hep [...]	0.759
CHURC1	RNF43	ENSP00000450144	ENSP00000385328	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	ring finger protein 43; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone	0.525
CHURC1	SETMAR	ENSP00000450144	ENSP00000373354	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	SET domain and mariner transposase fusion gene; Histone methyltransferase that methylates ’Lys-4’ and ’Lys-36’ of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 ’Lys-36’. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5’-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA	0.512
CHURC1	ZEB2	ENSP00000450144	ENSP00000302501	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	zinc finger E-box binding homeobox 2; Transcriptional inhibitor that binds to DNA sequence 5’- CACCT-3’ in different promoters. Represses transcription of E- cadherin	0.683
CHURC1	ZSWIM7	ENSP00000450144	ENSP00000382218	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	zinc finger, SWIM-type containing 7; Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents	0.735
COX19	CHCHD7	ENSP00000342015	ENSP00000306425	cytochrome c oxidase assembly homolog 19 (S. cerevisiae); May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity)	coiled-coil-helix-coiled-coil-helix domain containing 7	0.873
COX19	CHURC1	ENSP00000342015	ENSP00000450144	cytochrome c oxidase assembly homolog 19 (S. cerevisiae); May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity)	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	0.504
NPAS4	CHURC1	ENSP00000311196	ENSP00000450144	neuronal PAS domain protein 4; Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	0.523
NPAS4	PCDH17	ENSP00000311196	ENSP00000367151	neuronal PAS domain protein 4; Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene	protocadherin 17; Potential calcium-dependent cell-adhesion protein	0.462
PCDH17	CHURC1	ENSP00000367151	ENSP00000450144	protocadherin 17; Potential calcium-dependent cell-adhesion protein	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	0.620
PCDH17	NPAS4	ENSP00000367151	ENSP00000311196	protocadherin 17; Potential calcium-dependent cell-adhesion protein	neuronal PAS domain protein 4; Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene	0.462

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