node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMT | ATIC | ENSP00000273588 | ENSP00000236959 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | 0.941 |
AMT | DHFR | ENSP00000273588 | ENSP00000396308 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | 0.925 |
AMT | FTCD | ENSP00000273588 | ENSP00000291670 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | formiminotransferase cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool | 0.913 |
AMT | MTHFD1 | ENSP00000273588 | ENSP00000450560 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.981 |
AMT | MTHFR | ENSP00000273588 | ENSP00000365775 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | 0.930 |
AMT | SHMT1 | ENSP00000273588 | ENSP00000318868 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity) | 0.985 |
AMT | SHMT2 | ENSP00000273588 | ENSP00000333667 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA | 0.988 |
AMT | TYMS | ENSP00000273588 | ENSP00000315644 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | thymidylate synthetase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.929 |
ATIC | AMT | ENSP00000236959 | ENSP00000273588 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | 0.941 |
ATIC | DHFR | ENSP00000236959 | ENSP00000396308 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | 0.951 |
ATIC | FTCD | ENSP00000236959 | ENSP00000291670 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | formiminotransferase cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool | 0.913 |
ATIC | GART | ENSP00000236959 | ENSP00000371236 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | 0.998 |
ATIC | MTHFD1 | ENSP00000236959 | ENSP00000450560 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.989 |
ATIC | MTHFR | ENSP00000236959 | ENSP00000365775 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | 0.493 |
ATIC | SHMT1 | ENSP00000236959 | ENSP00000318868 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity) | 0.989 |
ATIC | SHMT2 | ENSP00000236959 | ENSP00000333667 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA | 0.990 |
ATIC | TYMS | ENSP00000236959 | ENSP00000315644 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | thymidylate synthetase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.830 |
DHFR | AMT | ENSP00000396308 | ENSP00000273588 | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | 0.925 |
DHFR | ATIC | ENSP00000396308 | ENSP00000236959 | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis | 0.951 |
DHFR | FTCD | ENSP00000396308 | ENSP00000291670 | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | formiminotransferase cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool | 0.921 |