| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DIO2 | FOSL2 | ENSP00000450980 | ENSP00000264716 | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | FOS-like antigen 2; Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity) | 0.810 |
| DIO2 | MARCH6 | ENSP00000450980 | ENSP00000274140 | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 | 0.835 |
| DIO2 | NKX2-1 | ENSP00000450980 | ENSP00000346879 | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis | 0.863 |
| DIO2 | NMU | ENSP00000450980 | ENSP00000264218 | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | neuromedin U; Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder | 0.807 |
| DIO2 | PPARA | ENSP00000450980 | ENSP00000262735 | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerizati [...] | 0.854 |
| DIO2 | SECISBP2 | ENSP00000450980 | ENSP00000364965 | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | SECIS binding protein 2; Binds to the SECIS element in the 3’-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB | 0.823 |
| DIO2 | UBC | ENSP00000450980 | ENSP00000344818 | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | ubiquitin C | 0.938 |
| DIO2 | UBE2G1 | ENSP00000450980 | ENSP00000380178 | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | ubiquitin-conjugating enzyme E2G 1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-, as well as ’Lys-63’-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4 | 0.812 |
| DIO2 | USP33 | ENSP00000450980 | ENSP00000350009 | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | ubiquitin specific peptidase 33; Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube [...] | 0.930 |
| DIO2 | WSB1 | ENSP00000450980 | ENSP00000262394 | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | WD repeat and SOCS box containing 1; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation | 0.954 |
| FOSL2 | DIO2 | ENSP00000264716 | ENSP00000450980 | FOS-like antigen 2; Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity) | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | 0.810 |
| FOSL2 | UBC | ENSP00000264716 | ENSP00000344818 | FOS-like antigen 2; Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity) | ubiquitin C | 0.724 |
| MARCH6 | DIO2 | ENSP00000274140 | ENSP00000450980 | membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | 0.835 |
| MARCH6 | UBC | ENSP00000274140 | ENSP00000344818 | membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 | ubiquitin C | 0.996 |
| MARCH6 | UBE2G1 | ENSP00000274140 | ENSP00000380178 | membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 | ubiquitin-conjugating enzyme E2G 1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-, as well as ’Lys-63’-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4 | 0.709 |
| NKX2-1 | DIO2 | ENSP00000346879 | ENSP00000450980 | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | 0.863 |
| NMU | DIO2 | ENSP00000264218 | ENSP00000450980 | neuromedin U; Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | 0.807 |
| PPARA | DIO2 | ENSP00000262735 | ENSP00000450980 | peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerizati [...] | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | 0.854 |
| SECISBP2 | DIO2 | ENSP00000364965 | ENSP00000450980 | SECIS binding protein 2; Binds to the SECIS element in the 3’-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | 0.823 |
| UBC | DIO2 | ENSP00000344818 | ENSP00000450980 | ubiquitin C | deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development | 0.938 |
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