node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHD7 | CHD8 | ENSP00000392028 | ENSP00000382863 | chromodomain helicase DNA binding protein 7; Probable transcription regulator | chromodomain helicase DNA binding protein 8 | 0.646 |
CHD7 | DUX4L6 | ENSP00000392028 | ENSP00000451253 | chromodomain helicase DNA binding protein 7; Probable transcription regulator | double homeobox 4 like 6 | 0.609 |
CHD8 | CHD7 | ENSP00000382863 | ENSP00000392028 | chromodomain helicase DNA binding protein 8 | chromodomain helicase DNA binding protein 7; Probable transcription regulator | 0.646 |
CHD8 | DUX4L6 | ENSP00000382863 | ENSP00000451253 | chromodomain helicase DNA binding protein 8 | double homeobox 4 like 6 | 0.609 |
CHD9 | DUX4L6 | ENSP00000455307 | ENSP00000451253 | chromodomain helicase DNA binding protein 9; Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity) | double homeobox 4 like 6 | 0.609 |
CYR61 | DUX4L6 | ENSP00000398736 | ENSP00000451253 | cysteine-rich, angiogenic inducer, 61; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alp [...] | double homeobox 4 like 6 | 0.678 |
DUX4L6 | CHD7 | ENSP00000451253 | ENSP00000392028 | double homeobox 4 like 6 | chromodomain helicase DNA binding protein 7; Probable transcription regulator | 0.609 |
DUX4L6 | CHD8 | ENSP00000451253 | ENSP00000382863 | double homeobox 4 like 6 | chromodomain helicase DNA binding protein 8 | 0.609 |
DUX4L6 | CHD9 | ENSP00000451253 | ENSP00000455307 | double homeobox 4 like 6 | chromodomain helicase DNA binding protein 9; Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity) | 0.609 |
DUX4L6 | CYR61 | ENSP00000451253 | ENSP00000398736 | double homeobox 4 like 6 | cysteine-rich, angiogenic inducer, 61; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alp [...] | 0.678 |
DUX4L6 | TBX6 | ENSP00000451253 | ENSP00000279386 | double homeobox 4 like 6 | T-box 6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells- neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity) | 0.756 |
DUX4L6 | TCF7 | ENSP00000451253 | ENSP00000340347 | double homeobox 4 like 6 | transcription factor 7 (T-cell specific, HMG-box); Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5’-WWCAAAG-3’) found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1 | 0.603 |
DUX4L6 | TCF7L1 | ENSP00000451253 | ENSP00000282111 | double homeobox 4 like 6 | transcription factor 7-like 1 (T-cell specific, HMG-box); Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance | 0.710 |
DUX4L6 | TCF7L2 | ENSP00000451253 | ENSP00000444972 | double homeobox 4 like 6 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.710 |
DUX4L6 | WNT8A | ENSP00000451253 | ENSP00000381739 | double homeobox 4 like 6 | wingless-type MMTV integration site family, member 8A; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus | 0.687 |
DUX4L6 | WNT8B | ENSP00000451253 | ENSP00000340677 | double homeobox 4 like 6 | wingless-type MMTV integration site family, member 8B; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus | 0.687 |
TBX6 | DUX4L6 | ENSP00000279386 | ENSP00000451253 | T-box 6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells- neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity) | double homeobox 4 like 6 | 0.756 |
TBX6 | TCF7 | ENSP00000279386 | ENSP00000340347 | T-box 6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells- neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity) | transcription factor 7 (T-cell specific, HMG-box); Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5’-WWCAAAG-3’) found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1 | 0.724 |
TBX6 | TCF7L1 | ENSP00000279386 | ENSP00000282111 | T-box 6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells- neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity) | transcription factor 7-like 1 (T-cell specific, HMG-box); Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance | 0.739 |
TBX6 | TCF7L2 | ENSP00000279386 | ENSP00000444972 | T-box 6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells- neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity) | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.739 |