DUX4 protein (Homo sapiens) - STRING network view

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DUX4

double homeobox 4 (485 aa)

Predicted Functional Partners:

ETV5

0.759

TBX6

0.756

POU5F1

0.726

TCF7L2

0.710

TCF7L1

0.710

WNT8A

0.687

WNT8B

0.687

CYR61

0.678

ETV1

0.621

CHD9

0.609

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHD9	DUX4	ENSP00000455307	ENSP00000451304	chromodomain helicase DNA binding protein 9; Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity)	double homeobox 4	0.609
CYR61	DUX4	ENSP00000398736	ENSP00000451304	cysteine-rich, angiogenic inducer, 61; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alp [...]	double homeobox 4	0.678
DUX4	CHD9	ENSP00000451304	ENSP00000455307	double homeobox 4	chromodomain helicase DNA binding protein 9; Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity)	0.609
DUX4	CYR61	ENSP00000451304	ENSP00000398736	double homeobox 4	cysteine-rich, angiogenic inducer, 61; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alp [...]	0.678
DUX4	ETV1	ENSP00000451304	ENSP00000385551	double homeobox 4	ets variant 1	0.621
DUX4	ETV5	ENSP00000451304	ENSP00000306894	double homeobox 4	ets variant 5; Binds to DNA sequences containing the consensus nucleotide core sequence GGAA	0.759
DUX4	POU5F1	ENSP00000451304	ENSP00000259915	double homeobox 4	POU class 5 homeobox 1	0.726
DUX4	TBX6	ENSP00000451304	ENSP00000279386	double homeobox 4	T-box 6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells- neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity)	0.756
DUX4	TCF7L1	ENSP00000451304	ENSP00000282111	double homeobox 4	transcription factor 7-like 1 (T-cell specific, HMG-box); Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance	0.710
DUX4	TCF7L2	ENSP00000451304	ENSP00000444972	double homeobox 4	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.710
DUX4	WNT8A	ENSP00000451304	ENSP00000381739	double homeobox 4	wingless-type MMTV integration site family, member 8A; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus	0.687
DUX4	WNT8B	ENSP00000451304	ENSP00000340677	double homeobox 4	wingless-type MMTV integration site family, member 8B; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus	0.687
ETV1	DUX4	ENSP00000385551	ENSP00000451304	ets variant 1	double homeobox 4	0.621
ETV5	DUX4	ENSP00000306894	ENSP00000451304	ets variant 5; Binds to DNA sequences containing the consensus nucleotide core sequence GGAA	double homeobox 4	0.759
POU5F1	DUX4	ENSP00000259915	ENSP00000451304	POU class 5 homeobox 1	double homeobox 4	0.726
POU5F1	TBX6	ENSP00000259915	ENSP00000279386	POU class 5 homeobox 1	T-box 6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells- neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity)	0.694
POU5F1	TCF7L1	ENSP00000259915	ENSP00000282111	POU class 5 homeobox 1	transcription factor 7-like 1 (T-cell specific, HMG-box); Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance	0.791
POU5F1	TCF7L2	ENSP00000259915	ENSP00000444972	POU class 5 homeobox 1	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.690
TBX6	DUX4	ENSP00000279386	ENSP00000451304	T-box 6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells- neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity)	double homeobox 4	0.756
TBX6	POU5F1	ENSP00000279386	ENSP00000259915	T-box 6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells- neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity)	POU class 5 homeobox 1	0.694

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