node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000259753 | ITGA7 | ENSP00000456711 | ENSP00000452120 | Integrin beta | integrin, alpha 7 | 0.931 |
ENSG00000259753 | THBS1 | ENSP00000456711 | ENSP00000260356 | Integrin beta | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | 0.839 |
ENSG00000259753 | TNC | ENSP00000456711 | ENSP00000265131 | Integrin beta | tenascin C; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6 | 0.805 |
ITGA7 | ENSG00000259753 | ENSP00000452120 | ENSP00000456711 | integrin, alpha 7 | Integrin beta | 0.931 |
ITGA7 | ITGB1 | ENSP00000452120 | ENSP00000303351 | integrin, alpha 7 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.999 |
ITGA7 | ITGB3 | ENSP00000452120 | ENSP00000262017 | integrin, alpha 7 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. [...] | 0.993 |
ITGA7 | ITGB4 | ENSP00000452120 | ENSP00000200181 | integrin, alpha 7 | integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility | 0.929 |
ITGA7 | ITGB5 | ENSP00000452120 | ENSP00000296181 | integrin, alpha 7 | integrin, beta 5; Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand | 0.995 |
ITGA7 | ITGB6 | ENSP00000452120 | ENSP00000283249 | integrin, alpha 7 | integrin, beta 6; Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion | 0.978 |
ITGA7 | ITGB7 | ENSP00000452120 | ENSP00000267082 | integrin, alpha 7 | integrin, beta 7; Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in M [...] | 0.947 |
ITGA7 | ITGB8 | ENSP00000452120 | ENSP00000222573 | integrin, alpha 7 | integrin, beta 8; Integrin alpha-V/beta-8 is a receptor for fibronectin | 0.968 |
ITGA7 | THBS1 | ENSP00000452120 | ENSP00000260356 | integrin, alpha 7 | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | 0.919 |
ITGA7 | TNC | ENSP00000452120 | ENSP00000265131 | integrin, alpha 7 | tenascin C; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6 | 0.912 |
ITGB1 | ITGA7 | ENSP00000303351 | ENSP00000452120 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | integrin, alpha 7 | 0.999 |
ITGB1 | ITGB3 | ENSP00000303351 | ENSP00000262017 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. [...] | 0.733 |
ITGB1 | ITGB4 | ENSP00000303351 | ENSP00000200181 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility | 0.909 |
ITGB1 | ITGB6 | ENSP00000303351 | ENSP00000283249 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | integrin, beta 6; Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion | 0.727 |
ITGB1 | ITGB7 | ENSP00000303351 | ENSP00000267082 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | integrin, beta 7; Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in M [...] | 0.903 |
ITGB1 | ITGB8 | ENSP00000303351 | ENSP00000222573 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | integrin, beta 8; Integrin alpha-V/beta-8 is a receptor for fibronectin | 0.732 |
ITGB1 | THBS1 | ENSP00000303351 | ENSP00000260356 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | 0.969 |