node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | ENSG00000258989 | ENSP00000349960 | ENSP00000452401 | actin, beta | Uncharacterized protein | 0.865 |
ACTB | RHOA | ENSP00000349960 | ENSP00000400175 | actin, beta | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.927 |
ARAF | BRAF | ENSP00000366244 | ENSP00000288602 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | v-raf murine sarcoma viral oncogene homolog B1 | 0.952 |
ARAF | ENSG00000258989 | ENSP00000366244 | ENSP00000452401 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | Uncharacterized protein | 0.807 |
ARAF | RAF1 | ENSP00000366244 | ENSP00000251849 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.587 |
ARAF | RHOA | ENSP00000366244 | ENSP00000400175 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.482 |
BRAF | ARAF | ENSP00000288602 | ENSP00000366244 | v-raf murine sarcoma viral oncogene homolog B1 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | 0.952 |
BRAF | ENSG00000258989 | ENSP00000288602 | ENSP00000452401 | v-raf murine sarcoma viral oncogene homolog B1 | Uncharacterized protein | 0.807 |
BRAF | MAP3K1 | ENSP00000288602 | ENSP00000382423 | v-raf murine sarcoma viral oncogene homolog B1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | 0.964 |
BRAF | RAF1 | ENSP00000288602 | ENSP00000251849 | v-raf murine sarcoma viral oncogene homolog B1 | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.999 |
BRAF | RHOA | ENSP00000288602 | ENSP00000400175 | v-raf murine sarcoma viral oncogene homolog B1 | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.427 |
ENSG00000258989 | ACTB | ENSP00000452401 | ENSP00000349960 | Uncharacterized protein | actin, beta | 0.865 |
ENSG00000258989 | ARAF | ENSP00000452401 | ENSP00000366244 | Uncharacterized protein | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | 0.807 |
ENSG00000258989 | BRAF | ENSP00000452401 | ENSP00000288602 | Uncharacterized protein | v-raf murine sarcoma viral oncogene homolog B1 | 0.807 |
ENSG00000258989 | MAP3K1 | ENSP00000452401 | ENSP00000382423 | Uncharacterized protein | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | 0.827 |
ENSG00000258989 | MAP3K15 | ENSP00000452401 | ENSP00000345629 | Uncharacterized protein | mitogen-activated protein kinase kinase kinase 15; May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis | 0.827 |
ENSG00000258989 | MAP3K5 | ENSP00000452401 | ENSP00000351908 | Uncharacterized protein | mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] | 0.827 |
ENSG00000258989 | MAP3K6 | ENSP00000452401 | ENSP00000350195 | Uncharacterized protein | mitogen-activated protein kinase kinase kinase 6; Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways | 0.827 |
ENSG00000258989 | RAF1 | ENSP00000452401 | ENSP00000251849 | Uncharacterized protein | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.807 |
ENSG00000258989 | RHOA | ENSP00000452401 | ENSP00000400175 | Uncharacterized protein | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.915 |