node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY3 | GPR176 | ENSP00000260600 | ENSP00000453076 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | G protein-coupled receptor 176; Orphan receptor | 0.755 |
ADCY3 | HTR5A | ENSP00000260600 | ENSP00000287907 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins | 0.900 |
ADCY3 | OXGR1 | ENSP00000260600 | ENSP00000298440 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | oxoglutarate (alpha-ketoglutarate) receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity) | 0.900 |
ADCY3 | P2RY13 | ENSP00000260600 | ENSP00000320376 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | purinergic receptor P2Y, G-protein coupled, 13; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system | 0.900 |
ADCY3 | PROK1 | ENSP00000260600 | ENSP00000271331 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | prokineticin 1; Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. [...] | 0.760 |
ADCY3 | PROK2 | ENSP00000260600 | ENSP00000295619 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | prokineticin 2; May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle | 0.748 |
GPR176 | ADCY3 | ENSP00000453076 | ENSP00000260600 | G protein-coupled receptor 176; Orphan receptor | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.755 |
GPR176 | GPR26 | ENSP00000453076 | ENSP00000284674 | G protein-coupled receptor 176; Orphan receptor | G protein-coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP | 0.751 |
GPR176 | GPR27 | ENSP00000453076 | ENSP00000303149 | G protein-coupled receptor 176; Orphan receptor | G protein-coupled receptor 27; Orphan receptor. Possible candidate for amine-like G- protein coupled receptor | 0.680 |
GPR176 | GPR87 | ENSP00000453076 | ENSP00000260843 | G protein-coupled receptor 176; Orphan receptor | G protein-coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage | 0.747 |
GPR176 | HTR5A | ENSP00000453076 | ENSP00000287907 | G protein-coupled receptor 176; Orphan receptor | 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins | 0.754 |
GPR176 | OPN5 | ENSP00000453076 | ENSP00000360255 | G protein-coupled receptor 176; Orphan receptor | opsin 5 | 0.759 |
GPR176 | OXGR1 | ENSP00000453076 | ENSP00000298440 | G protein-coupled receptor 176; Orphan receptor | oxoglutarate (alpha-ketoglutarate) receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity) | 0.748 |
GPR176 | P2RY13 | ENSP00000453076 | ENSP00000320376 | G protein-coupled receptor 176; Orphan receptor | purinergic receptor P2Y, G-protein coupled, 13; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system | 0.748 |
GPR176 | PROK1 | ENSP00000453076 | ENSP00000271331 | G protein-coupled receptor 176; Orphan receptor | prokineticin 1; Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. [...] | 0.749 |
GPR176 | PROK2 | ENSP00000453076 | ENSP00000295619 | G protein-coupled receptor 176; Orphan receptor | prokineticin 2; May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle | 0.667 |
GPR26 | GPR176 | ENSP00000284674 | ENSP00000453076 | G protein-coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP | G protein-coupled receptor 176; Orphan receptor | 0.751 |
GPR27 | GPR176 | ENSP00000303149 | ENSP00000453076 | G protein-coupled receptor 27; Orphan receptor. Possible candidate for amine-like G- protein coupled receptor | G protein-coupled receptor 176; Orphan receptor | 0.680 |
GPR87 | GPR176 | ENSP00000260843 | ENSP00000453076 | G protein-coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage | G protein-coupled receptor 176; Orphan receptor | 0.747 |
HTR5A | ADCY3 | ENSP00000287907 | ENSP00000260600 | 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.900 |