| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAM8 | IL13 | ENSP00000453302 | ENSP00000304915 | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | 0.815 |
| ADAM8 | IL4 | ENSP00000453302 | ENSP00000231449 | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | 0.815 |
| ADAM8 | ITGA9 | ENSP00000453302 | ENSP00000264741 | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | integrin, alpha 9; Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G- I-E-L in cytotactin | 0.906 |
| ADAM8 | ITGB1 | ENSP00000453302 | ENSP00000303351 | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.900 |
| ADAM8 | LPXN | ENSP00000453302 | ENSP00000431284 | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling | 0.729 |
| ADAM8 | MRPL13 | ENSP00000453302 | ENSP00000306548 | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | mitochondrial ribosomal protein L13 | 0.811 |
| ADAM8 | SELPLG | ENSP00000453302 | ENSP00000228463 | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | selectin P ligand; A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture | 0.806 |
| ADAM8 | SVIL | ENSP00000453302 | ENSP00000348128 | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | supervillin; Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adehesions involves binding to TRIP6 (By [...] | 0.731 |
| ADAM8 | VCAM1 | ENSP00000453302 | ENSP00000294728 | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | vascular cell adhesion molecule 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation | 0.732 |
| ADAM8 | WDR1 | ENSP00000453302 | ENSP00000427687 | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | WD repeat domain 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity) | 0.720 |
| IL13 | ADAM8 | ENSP00000304915 | ENSP00000453302 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | 0.815 |
| IL13 | IL4 | ENSP00000304915 | ENSP00000231449 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | 0.997 |
| IL13 | VCAM1 | ENSP00000304915 | ENSP00000294728 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | vascular cell adhesion molecule 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation | 0.954 |
| IL4 | ADAM8 | ENSP00000231449 | ENSP00000453302 | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | 0.815 |
| IL4 | IL13 | ENSP00000231449 | ENSP00000304915 | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | 0.997 |
| IL4 | VCAM1 | ENSP00000231449 | ENSP00000294728 | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | vascular cell adhesion molecule 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation | 0.926 |
| ITGA9 | ADAM8 | ENSP00000264741 | ENSP00000453302 | integrin, alpha 9; Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G- I-E-L in cytotactin | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | 0.906 |
| ITGA9 | ITGB1 | ENSP00000264741 | ENSP00000303351 | integrin, alpha 9; Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G- I-E-L in cytotactin | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.998 |
| ITGA9 | VCAM1 | ENSP00000264741 | ENSP00000294728 | integrin, alpha 9; Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G- I-E-L in cytotactin | vascular cell adhesion molecule 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation | 0.923 |
| ITGB1 | ADAM8 | ENSP00000303351 | ENSP00000453302 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | ADAM metallopeptidase domain 8; Possible involvement in extravasation of leukocytes | 0.900 |
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