Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | TMEM185B | transmembrane protein 185B (350 aa) | ||||||||||||
Predicted Functional Partners:
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 | GPR149 | G protein-coupled receptor 149; Orphan receptor (731 aa) |
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0.629 | ||||||||||
 | GPR107 | G protein-coupled receptor 107 (600 aa) |
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0.594 | ||||||||||
 | GPR108 | G protein-coupled receptor 108 (543 aa) |
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0.594 | ||||||||||
 | PAQR5 | progestin and adipoQ receptor family member V; Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (330 aa) |
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0.590 | ||||||||||
 | PAQR6 | progestin and adipoQ receptor family member VI (351 aa) |
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0.590 | ||||||||||
 | PAQR7 | progestin and adipoQ receptor family member VII; Steroid membrane receptor. Binds progesterone in vitro. May be involved in oocyte maturation (346 aa) |
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0.548 | ||||||||||
 | PAQR8 | progestin and adipoQ receptor family member VIII; Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity) (354 aa) |
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0.548 | ||||||||||
 | DPY19L4 | dpy-19-like 4 (C. elegans); Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins (By similarity) (723 aa) |
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0.504 | ||||||||||
 | UBC | ubiquitin C (685 aa) |
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0.483 | ||||||||||
 | MTRNR2L2 | MT-RNR2-like 2; Plays a role as a neuroprotective factor. Protects against death induced by multiple different familial Alzheimer disease genes and beta amyloid proteins in Alzheimer disease. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2. Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP (24 aa) |
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0.414 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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