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STRINGSTRING
NPAS3 NPAS3 PTCD1 PTCD1 PTCD2 PTCD2 POLRMT POLRMT KIAA0391 KIAA0391 DDX28 DDX28 ENSG00000248919 ENSG00000248919 PTCD3 PTCD3 TRMT10C TRMT10C METTL17 METTL17 UBC UBC
KIAA0391 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KIAA0391KIAA0391 (583 aa)    
Predicted Functional Partners:
TRMT10C
tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends (403 aa)
        score_image   score_image   0.942
ENSG00000248919
ATP5J2-PTCD1 readthrough (749 aa)
            score_image   0.851
PTCD1
pentatricopeptide repeat domain 1; Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3’ processing of mitochondrial tRNAs (749 aa)
            score_image   0.780
NPAS3
neuronal PAS domain protein 3; May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity) (933 aa)
            score_image   0.752
PTCD2
pentatricopeptide repeat domain 2; Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function (By similarity) (388 aa)
            score_image   0.711
PTCD3
pentatricopeptide repeat domain 3; Mitochondrial RNA-binding protein that has a role in mitochondrial translation (689 aa)
            score_image   0.623
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.620
METTL17
methyltransferase like 17; May be a component of the mitochondrial small ribosomal subunit (By similarity) (478 aa)
            score_image   0.598
DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28; May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (540 aa)
            score_image   0.578
POLRMT
polymerase (RNA) mitochondrial (DNA directed); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) (1230 aa)
            score_image   0.569
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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