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PRKACB PRKACB GTF2H2 GTF2H2 MMS19 MMS19 CCNT1 CCNT1 PRKACA PRKACA PHKG2 PHKG2 PHKA2 PHKA2 CALM1 CALM1 PHKA1 PHKA1 PYGL PYGL PHKB PHKB
"PHKG2" - phosphorylase kinase, gamma 2 in Homo sapiens
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PHKG2phosphorylase kinase, gamma 2 (testis); Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity) (406 aa)    
Predicted Functional Partners:
PHKA2
phosphorylase kinase, alpha 2 (liver); Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin (1235 aa)
      score_image score_image score_image score_image   0.994
PHKB
phosphorylase kinase, beta; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation (1093 aa)
        score_image score_image score_image   0.994
CALM1
calmodulin 1 (phosphorylase kinase, delta) (149 aa)
          score_image score_image   0.947
PHKA1
phosphorylase kinase, alpha 1 (muscle); Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin (1223 aa)
      score_image score_image   score_image   0.933
PYGL
phosphorylase, glycogen, liver; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) (847 aa)
          score_image score_image   0.928
MMS19
MMS19 nucleotide excision repair homolog (S. cerevisiae) (1030 aa)
          score_image score_image   0.924
CCNT1
cyclin T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat’s affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofa [...] (726 aa)
          score_image score_image   0.919
PRKACB
protein kinase, cAMP-dependent, catalytic, beta (398 aa)
    score_image     score_image   score_image 0.912
GTF2H2
general transcription factor IIH, polypeptide 2, 44kDa; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter (395 aa)
          score_image score_image   0.912
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] (351 aa)
    score_image     score_image   score_image 0.911
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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