Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | TUBGCP4 | tubulin, gamma complex associated protein 4; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (666 aa) | ||||||||||||
Predicted Functional Partners:
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 | TUBG1 | tubulin, gamma 1; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (451 aa) |
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0.999 | |||||||
 | TUBGCP5 | tubulin, gamma complex associated protein 5; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (1024 aa) |
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0.999 | ||||||||
 | TUBGCP2 | tubulin, gamma complex associated protein 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (902 aa) |
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0.999 | ||||||
 | TUBGCP3 | tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (907 aa) |
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0.999 | |||||||
 | TUBGCP6 | tubulin, gamma complex associated protein 6; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (1819 aa) |
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0.998 | |||||||
 | MZT1 | mitotic spindle organizing protein 1; Required for gamma-tubulin complex recruitment to the centrosome (82 aa) |
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0.998 | |||||||||
 | MZT2B | mitotic spindle organizing protein 2B (158 aa) |
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0.998 | ||||||||
 | NEDD1 | neural precursor cell expressed, developmentally down-regulated 1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle (667 aa) |
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0.978 | ||||||||
 | NINL | ninein-like; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis (1382 aa) |
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0.976 | ||||||||
 | TUBB4B | tubulin, beta 4B class IVb; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) (445 aa) |
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0.939 | ||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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